Drug-phosphorylating enzyme

Details Drug-phosphorylating enzyme Drug-phosphorylating enzyme

2007-08-03

2011-12-06

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007400, C435S135000

Reexamination Certificate

active

08071300

ABSTRACT:
The objects of the present invention are: elucidation of an enzyme that phosphorylates in vivo a compound such as (2R)-2-amino-2-methyl-4-[5-(5-phenylpentanoyl)thiophen-2-yl]butan-1-ol and provision of a method of phosphorylating the aforementioned compound; provision of a method of screening for a substance phosphorylated by the aforementioned enzyme; provision of a method of determining the ability of a subject to phosphorylate a test compound.Provision of a method of phosphorylating the aforementioned compound using a human fructosamine-3-kinase-related protein and/or fructosamine-3-kinase, and a method of determining the ability of a subject to phosphorylate a test compound.

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Szwergold, B., et al., “Human Fructosamine-3-Kinase: Purification, Sequencing, Substrate Specificity, and Evidence of Activity In Vivo,” Diabetes 50(9):2139-2147, Sep. 2001.

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