Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1987-11-23
1990-08-28
Draper, Garnette
Drug, bio-affecting and body treating compositions
Lymphokine
530390, 530391, 530389, A61K 3944, C07K 1528, C07K 1700
Patent
active
049523945
ABSTRACT:
There is disclosed a drug-monoclonal antibody conjugate wherein the antibody is linked to a antitumor drug using disulfide benzyl carbamate or carbonate as the linker. Also disclosed is a method of delivering an active antitumor drug to the site of tumor cells in a mammal by administering the drug-monoclonal antibody conjugate.
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Worrell, et al., Effect of Linkage Variation on Pharmacokinetics of Ricin A Chain-Antibody Conjugates in Normal Rats, Anti-Cancer Drug Design, pp. 179-188, (1986).
Saretorelli, Allan C., The Role of Mitomycin Antibiotics in the Chemotherapy of Solid Tumors, Biochemical Pharmacology, 35, No. 1, pp. 67-69, (1986).
Gallego, et al., Preparation of Four Daumonycin-Monoclonal Antibody 791T/36 Conjugates with Antitumor Activity, Int. J. Cancer, 33, 737-744 (1984).
Endo, et al., In Vitro Cytoxicity of a Human Serum-Albumin-Mediated Conjugate of a Methotrexate With Anti-MM46 Monoclonal Antibody, Cancer Research, 47, 1076-1080 (1987).
Teicher and Sartorelli, Design of Models For Testing Cancer Therapeutic Agents, Van Nostrand Reinhold Co., N.Y., pp. 19-36 (1982).
Bristol-Myers Company
Cepeda Michelle A.
Draper Garnette
Kim Kay K.
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