Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1995-02-07
1996-10-08
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424427, 424429, 604264, 604266, A61K 910, A61K 4734, A61L 2700, A61L 3300
Patent
active
055629229
ABSTRACT:
In accordance with the present invention, there are provided prosthetic articles having polyurethane coatings with biologically active compounds incorporated within the interstices of the polymer. Methods for the preparation of such articles are also provided. Thus, a polyurethane coating is applied to a prosthetic article, the coating then swelled (without significantly dissolving the polymer) so that substantial quantities of biologically active compounds can be incorporated within the interstices of the polymer. Upon long term exposure of a prosthetic article of the invention to physiological conditions, the biologically active compound is slowly released by the treated polymer. The biologically active compound is, therefore, released only at the site where it is desired, i.e., where the prosthetic article is positioned.
REFERENCES:
patent: Re32991 (1989-07-01), Szycher et al.
patent: 3585647 (1968-04-01), Gajewski et al.
patent: 3853804 (1973-07-01), Yen et al.
patent: 4292965 (1981-10-01), Nash et al.
patent: 4447590 (1983-04-01), Szycher et al.
patent: 4582717 (1986-04-01), von Bittera et al.
patent: 4605564 (1986-08-01), Kulla et al.
patent: 4612337 (1986-09-01), Fox, Jr. et al.
patent: 4713402 (1987-12-01), Solomon
patent: 4731080 (1988-03-01), Galin
patent: 4749585 (1988-06-01), Greco et al.
patent: 4869909 (1989-09-01), Takahashi et al.
patent: 4879135 (1989-11-01), Greco et al.
patent: 4909799 (1990-03-01), Thulesius et al.
patent: 4925668 (1990-05-01), Khan et al.
patent: 5019096 (1991-05-01), Fox, Jr. et al.
patent: 5066298 (1991-11-01), Hess
patent: 5118779 (1992-06-01), Szycher
Cedars-Sinai Medical Center
Webman Edward J.
Whiteford, Esq. Wendy A.
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