Drug formulations comprising coated, very sparingly water-solubl

Details Drug formulations comprising coated, very sparingly water-solubl Drug formulations comprising coated, very sparingly water-solubl

1994-07-13

1997-09-02

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424 45, 424 46, 424490, 424491, 424494, 424496, 424497, 424499, 424500, A61K 3134

Patent

active

056631987

ABSTRACT:
Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation.
Drug formulations comprising micronized particles of very sparingly water-soluble drugs which are coated with a natural, physiologically acceptable ampholytic surfactant soluble in water to give a micellar/colloidal solution, and a process for the preparation of these drug formulations, are described. When placed in an appropriate final container and after the addition of a chlorine-free, partially fluorinated propellant gas liquefiable under pressure, these formulations are suitable for inhalation.

REFERENCES:
patent: 5230884 (1993-07-01), Evans et al.
Karl, Thoma, "Aerosole"; pp. 154-160; Frankfurt/Main (1987).
European Search Report dated Jul. 15, 1994.
Glant et al., Immunopharmacology, 23, 1992, pp. 105-116.
Zielinski et al., Immunobiology,186(1-2), 1992, p. 113.
Bartlett et al., Agents and Actions, 32(1/2), 1991, pp. 10-21.
Zielinski et al., Agents Actions, 38, 1993, pp. C80-C82.
Mattar et al., FEBS Letters, 334(2), 1993, pp. 161-164.

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