Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-05-25
1997-08-26
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514403, 514406, A61K 31415, A61K 31495
Patent
active
056611501
ABSTRACT:
A drug containing a calmodulin inhibitor as an active ingredient is disclosed. This drug is useful in the suppression of neuronal cell death, in particular brain neuronal cell death, due to, for example, cerebral ischemia.
Also, a drug containing a compound capable of inhibiting binding of calmodulin to a cytoskeltal protein as an active ingredient and a drug containing a compound suppressing the breakdown of a cytoskeltal protein as an active ingredient are disclosed.
These drugs are useful in the treatment and prevention of various diseases in the brain and sequelae thereof as well as in the prevention of relapses of these diseases.
REFERENCES:
Pohorecki, Roman et al., "Ketamine, MK-801 or Calmidazolium Protects Rat Hippocampal Energy Status During in Vitro Ischemia", Ann. N. Y. Acad. Sci., vol. 625 (1991) pp. 818-820.
Zivin, Justin A. et al., "Phenothiazines reduce ischemic damage to the central nervous system", Brain Res., vol. 482, No. 1, (1989) pp. 189-193.
Yu, Melvin J., Ph.D. et al., "A Phenothiazine Derivative Reduces Rat Brain Damage After Global or Focal Ischemia", Stroke, vol. 23, No. 9, (1992) pp. 1287-1291.
Seubert, P. et al., "Calmodulin Stimulates the Degradation of Brain Spectrin by Calpain", Synapse, vol. 1, No. 1, (1987) pp. 20-24.
Harris et al., J. Biol. Chem., vol. 264, No. 29, pp. 17401-17408. Oct. 15, 1989.
Kogure et al., Tanpakushitsu, Kakusan, Koso, vol. 35, pp. 1254-1271. 1990.
Hara et al., J. Cerebral Blood Flow and Metabolism, vol. 10, pp. 646-653. 1990.
Shirasaki Yasufumi
Yamaguchi Hitoshi
Daiichi Pharmaceutical Co. Ltd.
Raymond Richard L.
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