Drug for enhancing liver growth and method of preparing same

Details Drug for enhancing liver growth and method of preparing same Drug for enhancing liver growth and method of preparing same

1980-03-17

1982-07-27

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112R, 424106, 424177, A61K 3514, A61K 3700, A61K 35407, C07G 700

Patent

active

043417655

ABSTRACT:
A factor which causes an increase in the number of liver cells through increased cell division activity, obtained by homogenizing the remaining livers of partially hepatectomized animals, subjecting the homogenate to acidification to pH=5.5 and then heat treatment at 95.degree. C., and centrifuging said homogenate. After such treatment, the factor is contained in the supernatant. The factor is a neuraminic-acid-free protein with a molecular weight of approximately 30,000 to 50,000 D. An extract containing the factor also can be obtained from the blood plasma of hepatectomized animals, when the plasma in addition to the described steps further is treated with neuraminidase. Similarly, an extract containing the factor can be obtained from the livers or the plasma of non-hepatectomized fetal or very young animals.

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Bauer et al., Hoppe-Seyler's, Z. Physiolo. Chem. Bd., 359, S.543-545, (19. )

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