Drug for auditory dysfunction

Details Drug for auditory dysfunction Drug for auditory dysfunction

2008-06-24

2008-06-24

Wilson, Michael C. (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C514S04400A

Reexamination Certificate

active

07390482

ABSTRACT:
The present invention provides a pharmaceutical preparation for hearing impairment, which is suitable for gene therapy of hearing impairment, that is, a pharmaceutical preparation for hearing impairment which comprises a virus envelope vector encapsulating a hepatocyte growth factor (HGF) gene or its plasmid as an active ingredient. Particularly, it is suitable as a pharmaceutical preparation for gene therapy for the purpose of prevention and treatment of deafness.

REFERENCES:
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Kinoshita et al. (1992) Jikken Igaku 10(3):330-339 and summary in English.
Maina et al. (1997) “Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons” Genes & Dev. 11:3341-3350 (1997).
Wada et al. (1998) Audiology Japan 41(5):355-356 and summary in English.
Fisher “Genes and protein in renal development” Exp. Nephrol. 10:102-113 (2002) abstract only.
Korhonen et al. “Expression of c-Met in developing rat hippocampus: Evidence for HGF as a neurotrophic factor for calbindin D-expressing neurons” Eur. J. Neurosci. 12:3453-3461 (2000).

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