Drug flux enhancer-tolerant pressure sensitive adhesive composit

Details Drug flux enhancer-tolerant pressure sensitive adhesive composit Drug flux enhancer-tolerant pressure sensitive adhesive composit

1995-03-17

1996-11-12

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1302

Patent

active

055737781

ABSTRACT:
A drug flux enhancer-tolerant pressure sensitive adhesive composition is provided comprised of a mixture of (1) a percutaneous penetration enhancer to increase permeability of skin to transdermally administered pharmacologically active agents and (2) a macromer reinforced base polymer, said base polymer comprising a phase separated graft copolymer composition comprised of copolymerized monomers A and B to form a backbone polymer having polymeric moieties grafted thereto, wherein monomer A is a monomeric acrylic or methacrylic ester of a non-tertiary alcohol having from 1 to 14 carbon atoms, with the average number of carbon atoms being in the range of about 4 to 12, and a monomer B is a polar monomer which is copolymerizable with monomer A.

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Pfister, William R. et al., Permeation Enhancers Compatible with Transdermal Drug Delivery Systems Part 1: Selection and Formulation Considerations, Pharmaceutical Technology, pp. 132-140, Sep. 1990.
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