Drug excipient of silicone rubber

Details Drug excipient of silicone rubber Drug excipient of silicone rubber

1976-12-23

1980-10-28

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

128260, A61K 922, A61K 926

Patent

active

042306868

ABSTRACT:
Nontoxic sustained release pharmaceutical compositions containing one or more nonionic, lipophilic drugs in a cured low temperature vulcanizable (LTV) silicone elastomer excipient are prepared substantially free of toxic vulcanizing agents or drug-reactive by-products in the elastomeric material by curing an admixture of the drug or drug containing core, LTV-methylvinylsiloxane units containing linear dimethylpolysiloxane and a dimethylpolysiloxane crosslinking composition containing silicon linked H atoms using a noble metal-based catalyst. The resultant compositions are characterized by good physical properties and a constant rate of drug release in the body over long periods of time.

REFERENCES:
patent: 2823218 (1958-02-01), Speir et al.
patent: 3020260 (1962-02-01), Nelson
patent: 3127363 (1964-03-01), Nitzsche et al.
patent: 3220972 (1965-11-01), Lamoreaux
patent: 3279996 (1966-10-01), Long et al.
patent: 3699073 (1972-10-01), Wada et al.

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