Drug effect-enhancing agent for antitumor drug

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514 89, 514 90, 540542, 540575, 544125, 544337, 544365, 546 21, 546193, 546194, 546256, 546257, 546263, A61K 3144, A61K 3155, A61K 31535, A61K 31675

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051303035

ABSTRACT:
Compounds of the formula (I): ##STR1## in which the nitrogen-containing hetero ring portion is a 1,4-dihydropyridine ring or a pyridine ring, R.sup.1 is only present when the nitrogen-containing hetero ring is a 1,4-dihydropyridine ring, and Z is either a CO.sub.2 R.sup.8 group or a group of the formula (II): ##STR2## in which R.sup.4 and R.sup.5 may be the same or different and together may form one divalent group, are effective agents for enhancing the antitumor effect or antitumor drugs.

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