Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1990-10-11
1994-08-30
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424485, 424486, A61K 920
Patent
active
053426282
ABSTRACT:
A drug diffusion polymer system for the sustained release of drugs includes a composition comprising a polymeric matrix containing a uniform dispersion of a matrix expander and a drug. The matrix expander and drug are each present in the form of solid particulate. Upon exposure to body fluid or water, the matrix expander swells to cause the ingress of fluid into the polymeric matrix for solubilizing and diffusing the drug. Devices may incorporate such drug diffusion compositions as a coating or as a primary material of construction. Such devices may be formed by molding the compositions at room or elevated temperatures depending on the polymer used.
REFERENCES:
patent: 4764380 (1988-08-01), Urquhart et al.
patent: 4839177 (1989-06-01), Colombo et al.
A. R. Gennardo. (1985). Remington's Pharmaceutical Sciences, 17th ed. Mack Pub. pp. 1298, 1601, 1299.
Applied Medical Research, Inc.
Bawa Raj
Page Thurman K.
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