Drug diffusion polymer system and method

Details Drug diffusion polymer system and method Drug diffusion polymer system and method

1990-10-11

1994-08-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424485, 424486, A61K 920

Patent

active

053426282

ABSTRACT:
A drug diffusion polymer system for the sustained release of drugs includes a composition comprising a polymeric matrix containing a uniform dispersion of a matrix expander and a drug. The matrix expander and drug are each present in the form of solid particulate. Upon exposure to body fluid or water, the matrix expander swells to cause the ingress of fluid into the polymeric matrix for solubilizing and diffusing the drug. Devices may incorporate such drug diffusion compositions as a coating or as a primary material of construction. Such devices may be formed by molding the compositions at room or elevated temperatures depending on the polymer used.

REFERENCES:
patent: 4764380 (1988-08-01), Urquhart et al.
patent: 4839177 (1989-06-01), Colombo et al.
A. R. Gennardo. (1985). Remington's Pharmaceutical Sciences, 17th ed. Mack Pub. pp. 1298, 1601, 1299.

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