Drug delivery via therapeutic hydrogels

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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424484, 424485, 424486, 606191, 606194, 604 27, 604 53, A61K 9127, A61M 2500

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active

061327654

ABSTRACT:
The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.

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