Drug delivery using terminal complement components

Details Drug delivery using terminal complement components Drug delivery using terminal complement components

1996-04-30

2000-05-23

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241841, 4242361, 514 2, 514 44, 5303871, 530350, 536 221, A61K 39395

Patent

active

060663197

ABSTRACT:
Methods for treatment of a subject with therapeutic or diagnostic agents by delivery of the therapeutic or diagnostic agents to the subject via sublytic amounts of terminal complement membrane attack acomplex (MAC) transmembrane channels are described. Also described are methods for delivery of therapeutic or diagnostic agents to cells in vitro via sublytic amounts of MAC transmembrane channels. Pharmaceutical preparations containing MAC transmembrane channel forming agents and kits for the formation of sublytic amounts of MAC transmembrane channels also are provided.

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