Drug delivery using pH-sensitive semi-interpenetrating network h

Details Drug delivery using pH-sensitive semi-interpenetrating network h Drug delivery using pH-sensitive semi-interpenetrating network h

1997-03-14

1999-05-18

Brouillette, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424443, 424489, A61F13/00

Patent

active

059049278

ABSTRACT:
Drug-delivery devices and methods of their use are disclosed, which devices consist of at least a semi-interpenetrating network (semi-IPN) hydrogel comprising a first, cationic polymer such as chitosan and a second high molecular weight neutral polymer such as polyethylene oxide, the semi-IPN having been freeze-dried after formation of the semi-IPN, and a drug composition. A therapeutic method of treating gastric disease is also disclosed comprising the step(s) of introducing to a gastric area to be treated a drug-delivery device according to the disclosure, whereupon the device releases the drug or therapeutic agent contained in the device. The hydrogels of the disclosure are advantageously used for site-specific drug delivery in the gastro-intestinal tract where there is a range of pH from 1.0 to 1.5 in the stomach to about 7.5 in the small intestine.

REFERENCES:
patent: 4933182 (1990-06-01), Higashi et al.
patent: 5306550 (1994-04-01), Nishiyama et al.
Amiji, "Permeability and Blood Compatibility Properties of Chitosan-Poly (ethylene oxide) Blend Membranes for Haemodialysis", Biomaterials, 16:593-599, 1995.
Patel et al., "pH-Sensitive Swelling and Drug-Release Properties of Chitosan-Poly (ethylene oxide) Semi-interpenetrating Polymer Netword", Hydrogels and Biodegradable Polymers for Bioapplications pp. 209-220, 1996.
Patel et al., "Preparation and Characterization of Freeze-dried Chitosan-Poly (ethylene oxide) Hydrogels for Site-Specific Antibiotic Delivery in the Stomach", Pharmaceutical Research, 13:588-593, 1996.

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