Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1992-10-30
1996-01-09
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424485, 424 7838, 424 7831, 424 7837, 424451, A61K 914
Patent
active
054827191
ABSTRACT:
A photoactivatable drug delivery system is provided, in which a drug is combined e.g. by covalent bonding, incorporation in a matrix or encapsulation, with a photosensitive macromolecule. In combination, the drug is inert. The macromolecule is large enough to prevent migration of the combination within the body, so that the combination can be implanted at a location of maximum effectiveness. The drug is released from the combination, in therapeutically active form, upon appropriate irradiation.
REFERENCES:
patent: 4766037 (1988-09-01), Watanabe et al.
patent: 5258453 (1993-11-01), Kopecek et al.
Mamada et al., "Photoinduced Phase Transition of Gels", Macromolecules 1990, 23, 1517-1519.
Kwon, et al., "Nature" (1991), 354,291-293.
Peterson et al., "Controlled Release of Bioactive Materials"; Ed. by Richard Baker, RS/201/D415/1979 pp. 45-53.
Collect. Czech Chem. Commun., 1987, vol. 52, pp. 1352-1355, Younes, M. E. et al. "Synthesis of Elastin-Like Peptides Using the Liquid Phase Method".
Chemical Abstracts, vol. 107, No. 23, 7 Dec. 1987, Columbus Ohio, US; abstract No. 214271, Yen, Hung Ren et al., "Synthetic Water-Soluble Copolymers for Optically-Controlled Ligand Delivery" see abstract & Poly. Mater. Sci. Eng. 1987, vol. 57 pp. 243-247.
Journal of the American Chemical Society, vol. 97, No. 6, 19 Mar. 1975, Washington, D.C., U.S.A., pp. 1575-1579 D. H. Rich & S. K. Gurwara "Preparation of a New O-Notribenzyl Resin for Solid-Phase Synthesis . . . " Cited in the appln. see whole doc.
Bioconjugate Chem., vol. 3, No. 2, pp. 104-107, Mar./Apr. 1992, Goldmacher V S et al "Photoactivation of Toxin Conjugate" see whole document.
Biological Abstracts, vol. 81, Philadelphia, Pa. US; Abstract No. 015704 Senter P D et al. "Novel Photocleavage Protein Crosslinking . . . " see abstract & Photochemistry and Photobiology, vol. 42, No. 3 pp. 232-238, 1984.
Chemical Abstracts, vol. 110, No. 11, 13 Mar. 1989, Columbus, Ohio, US; abstract No. 095775, Yoneis, M. E. et al. `An Improved Application of the Photosensitive . . . ` see abstract & J. Indian Chem. Soc., 1988 vol. 65, pp. 498-499.
Chemical Abstracts, vol. 110, No. 22, 29 May 1989, Columbus, Ohio, US; abstract No. 193552, Yen, Hung Ren et al. "Optically Controlled Ligand Delivery . . . " see abstract & Makromol. Chem. 1989, vol. 190, pp. 69-82.
Biochem Int. Apr. 1992, vol. 26, No. 5, pp. 943-951, Marriott G et al. "Photomodulation of the Nucleating Activity of a Photocleavable Crosslinked Acting Dimer" see Abstract.
Proc Natl Acad Sci USA, Dec. 1980, vol. 77, No. 12, pp. 7237-7241, McCray J. A. et al. "A New Approach to Time-Resolved Studies of ATP-Requiring Biological Systems . . . " see p. 7237, see p. 7240.
Chem. Lett., 1989, No. 3, pp. 433-436, Kusumi, Akihiro et al "Liposomes That Can Be Disintegrated By Photo-Irradiation".
Bioconjugate Chem. 1990, vol. 1, No. 4, pp. 296-304. Koch Troels et al. "The Oxidative Cleavability of Protein Cross-Linking Reagents Containing Organoselenium Bridges" pp. 297-298.
Pharmazie, vol. 32, No. 11, Nov. 1977, Berlin DD, Pawelczyk E. et al. "Kinetics of Drug Decomposition Part 51: Kinetics of Indometacine Photodegradation".
Bakhtiyari Hamid
Guillet James E.
Benston, Jr. William E.
Page Thurman K.
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