Drug delivery system for two or more active substances

Details Drug delivery system for two or more active substances Drug delivery system for two or more active substances

1998-04-08

1999-11-23

Azpuru, C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424430, 424432, A61F 1302

Patent

active

059895810

ABSTRACT:
The present invention is dealing with a drug delivery system, preferably in a ring-shaped form suitable for vaginal administration, for the simultaneous release of a progestogenic steroid compound and an estrogenic steroid compound in a fixed physiological ratio over a prolonged period of time. The drug delivery system comprises at least one compartment comprising a thermoplastic polymer core containing the mixture of the progestogenic and estrogenic compounds and a thermoplastic polymer skin, the progestogenic compound being initially dissolved in the polymer core material in a relatively low degree of supersaturation.

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