Drug delivery system for accelerated subcutaneous absorption

Details Drug delivery system for accelerated subcutaneous absorption Drug delivery system for accelerated subcutaneous absorption

2004-06-25

2009-08-11

Davis, Ruth A (Department: 1651)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S201000

Reexamination Certificate

active

07572613

ABSTRACT:
A method for accelerating subcutaneous absorption of a fluid or drug into the systemic circulation of a specific targeted tissue. A first drug operative to produce local capillary vasodilatation and/or increase the rate of bulk flow of solution through the interstitial space is mixed with a fluid. The fluid may contain a crystalloid solution or a dilute solution of a pharmacologic drug required for a routine or emergency therapeutic treatment for a patient. The first drug is substantially non-toxic to the patient. The fluid mixed with the first drug is then delivered subcutaneously or into deeper tissues of the patient, by use of a hyperdermic needle or infiltration cannula. As the capillaries are dilated, the fluid is efficiently absorbed and circulated systemically.

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Evora et al., J Thorac Cardiovac Surg, 2000, 120:707-711, abstract.

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