Drug delivery system

Details Drug delivery system Drug delivery system

1987-01-15

1990-02-27

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 78, 424491, 424493, 424496, 424497, A61K 914, A61K 4508

Patent

active

049044796

ABSTRACT:
Particles of a drug are directed away from the reticuloendothelial system by the use of surface coating and surface grafting techniques which substantially prevent the take up of the composite particles by the liver.

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patent: 4474752 (1984-10-01), Haslam et al.
patent: 4474753 (1984-10-01), Haslam et al.
patent: 4478822 (1984-10-01), Haslam et al.
patent: 4533542 (1985-08-01), Buddenbaum et al.
patent: 4556670 (1985-12-01), Lipinski
patent: 4620974 (1986-11-01), Hersh et al.
patent: 4668704 (1987-05-01), Hollander et al.
patent: 4670468 (1987-06-01), Hollander et al.
"Effects of the Nonionic Surfactant Ploxamer 338 on the Fate and Deposition of Polystyrene Microspheres Following Intravenous Administration", by Lisbeth Illum and Stanley S. Davis Journal of Pharmaceutical Sciences, vol. 72, No. 9, Sep., 1983, pp. 1086-1089.
"The Organ Uptake of Intravenously Administered Colloidal Particles can be Altered Using A Non-Ionic Surfactant (Poloxamer 338)", L. Illum and S. S. Davis, FEBS Lettersm, vol. 167, No. 1, Feb. 1984, pp. 79-82.
"The Effect of Hydrophilic Coatings on the Uptake of Colloidal Particles by the Liver and by Peritoneal Macrophases", By L. Illum, I. M. Hunneyball and S. S. Davis, International Journal of Pharmaceuticals, vol. 29, 1986, pp. 53-65.
Thesis: "Microspheres and Site Specific Delivery", Lisbeth illum, Royal Danish School of Pharmacy, Department of Pharmaceutics, Copenhagen, 1987.
"The Organ Distribution and Circulation Time of Intravenously Injected Colloidal Carriers Sterically Stabilized with a Block Copolymer-Poloxamine 908", By L. Illum, S. S. Davis, R. H. Muller, E. Mak and P. West, Life Sciences, vol. 40, pp. 367-374, 1987.
"Targeting of Colloidal Particles to the Bone Marrow", By L. Illum and S. S. Davis, Life Sciences, vol. 40, pp. 1553-1560, 1987.

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