Drug delivery ophthalmic insert and method of preparing same

Details Drug delivery ophthalmic insert and method of preparing same Drug delivery ophthalmic insert and method of preparing same

1991-10-01

1993-07-20

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424428, 424429, 264 11, 264 16, 264 26, 264 13, 2641761, 514777, 514779, 523106, B29B 906, B28B 320, A61F 214, A61K 914

Patent

active

052291286

ABSTRACT:
A drug delivery ophthalmic insert prepared by forming a water soluble solid polymer into a paste by the addition of a small fixed amount of water, drying the paste and then sectioning the paste into a plurality of rod shaped inserts is provided. The insert is rendered suitable for prolonged and sustained delivery of medication to the eye since it is formed by the addition of a small amount of water and has a surface area less than about 3 mm.sup.2. Specific water soluble solid polymers which may be used include methylcellulose, hydroxyethyl cellulose, alginic acid and combinations thereof as well as mixtures of pilocarpine dispersed in methylcellulose and its combinations.

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