Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Nitrates or nitrites or nitric acid or nitrogen oxides
Patent
1994-11-14
1997-07-15
Pak, John
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Nitrates or nitrites or nitric acid or nitrogen oxides
424400, 424449, 424451, 424463, 424464, 424474, 424475, 424484, 424486, 424489, 424490, 424497, 424501, 424648, 424DIG15, 514929, 514966, 514967, 514968, 514969, A61K 3300, A61K 3326, A61K 902, A61K 914
Patent
active
056481012
ABSTRACT:
A method of delivering NO gas to a desired situs on or in the body of a sentient animal, e.g. humans, comprising combining and causing to react a soluble reducing salt, preferably ferrous sulfate, and a nitrite, preferably sodium nitrite, as reactants in the presence of moisture in situ at or adjacent such situs. Means for such delivery include compositions such as tablets, capsules, ointments, creams, lotions, and sprays containing mixtures of particles or granules of the two reactants, and transdermal patches and osmotic pumps for combining solutions of reactant or reactants in situ.
REFERENCES:
patent: 5234956 (1993-08-01), Lipton
patent: 5583101 (1996-12-01), Stamler et al.
Johnson, III. Gerald et al., "Cardioprotective Effects of Acidified Sodium nitrite in myocardial ischemia with reperfusion", The Journal of Pharmacology and Experimental Therapeutics, vol. 252(1), pp. 35-41, 1990.
Cotton, F. Albert et al., Advanced Inorganic Chemistry, 5th ed., John Wiley & Sons, New York, 1988, pp. 321-323.
Biological Abstracts 89(9):96652, 1990; abstracting, Johnson et al., "Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion," J. Pharmacol. Exp. Ther., vol. 252(1), 1990, pp. 35-41.
Martindale The Extra Pharmacopoeia, (Reynolds et al. eds.), 13th ed., The Pharmaceutical Press, London, 1993, pp. 1220-1221.
The Merck Index, 10th ed., Merck & Co., Inc., Rahway (NJ), 1983, pp. 330-331.
Leavitt Michael A.
Leavitt Samson B.
Pak John
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