Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-02
1997-07-22
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 26, 514 33, 514 35, 514160, 514171, 514946, 514947, 536 5, A61K 3170, A61K 31705, A61K 3160, A61K 3156
Patent
active
056503989
ABSTRACT:
Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract useful in pharmaceutical compositions for enhancing the transport of pharmacologically active substances across mucous membranes of an animal. Also disclosed are modified saponins having reduced irritability wherein the aldehyde group is reduced and the fatty acid moiety may be removed by hydrolysis. Also disclosed are pharmaceutical compositions comprising the modified saponins of the invention.
REFERENCES:
patent: 4335113 (1982-06-01), Combier et al.
patent: 4443432 (1984-04-01), Garabedian et al.
patent: 4548922 (1985-10-01), Carey et al.
patent: 4550022 (1985-10-01), Garabedian et al.
patent: 4938970 (1990-07-01), Hustead et al.
patent: 4985253 (1991-01-01), Fujioka et al.
patent: 5057540 (1991-10-01), Kensil et al.
patent: 5118676 (1992-06-01), Minaskanian et al.
patent: 5118692 (1992-06-01), Peck
patent: 5166139 (1992-11-01), Bombardelli et al.
patent: 5182258 (1993-01-01), Chiou
Bomford, R., Saponin and Other Haemolysins (Vitamin A, Aliphatic Amines, Polyene Antibiotics) as Adjuvants for SRBC in the Mouse: Evidence for a Role for Cholesterol-Binding in Saponin Adjuvanticity, Int. Archs Allergy appl. Immun. 63:170-177 (1980).
Bomford, R., Studies on the Cellular Site of Action of the Adjuvant Activity of Saponin for Sheep Erythrocytes, Int. Archs Allergy appl. Immun. 67:127-131 (1982).
Chavali, S.R. et al., Adjuvant Effects of Orally Administered Saponins on Humoral and Cellular Immune Responses in Mice, Immunobiol. 174(3):347-359 (1987).
Chiou, G.C.Y. et al., Improvement of Systemic Absorption of Insulin through Eyes with Absorption Enhancers, Journal of Pharmaceutical Science 78:815-818 (1989).
Chiou, G.C.Y. et al., Reduction of Blood Glucose Concentration with Insulin Eye Drops, Diabetes Care 11:750-751 (1988).
Chiou, G.C.Y. et al., Systemic Delivery of Insulin through Eyes to Lower Glucose Concentration, Journal of Ocular Pharmacology 5:81-91 (1989).
Coughlin, R.T. et al., Purified Saponin Species From Ouillaja saponaria Are Adjuvants For T Independent Antigens, The FASEB Journal, American Society for Biochemistry and Molecular Biology, The American Association of Immunologists Joint Meeting, New Orleans, p. A2071, Abstract No. 2190 (1990).
Dalsgaard, K., Saponin Adjuvants. III. Isolation of a Substance from Quallaja saponaria Molina with Adjuvant Activity in Foot-and-Mouth Disease, Archiv fur die gesamte Virusforschung 44:243-254 (1974).
Egerton J.R. et al., Effect Of Quil A, A Saponin Derivative, On The Response Of Sheep To Alum Precipitated Bacteroides nodosus Vaccines, Veterinary Science Communications 2:247-252 (1978).
Higuchi, R. et al., An Acylated Triterpenoid Saponin From Quillaja saponaria, Phytochemistry 27 (4):1165-1168 (1988).
Higuchi, R. et al., Structure Of Desacylsaponins Obtained From The Bark Of Quillaja saponaria, Phytochemistry 26(1) :229-235 (1987).
Higuchi, R. et al., Structures Of Compounds Derived From The Acyl Moieties Of Quillajasaponin, Phytochemistry 26(8) :2357-2360 (1987).
Hirai, S. et al., Effect of Surfactants on the Nasal Absorption of Insulin in Rats, International Journal of Pharmaceutics 9:165-172 (1981).
Hirai, S. et al., Mechanisms for the Enhancement of the Nasal Absorption of Insulin by Surfactants, International Journal of Pharmaceutics 9:173-184 (1981).
Hirai, S. et al., Nasal Absorption of Insulin in Dogs, Diabetes 27:296-299 (1978).
International Search Report to Accompany International Application No. PCT/US93/06348, filed Jul. 1, 1993, Report mailed Sep. 24, 1993.
Kensil, C.R. et al., Separation And Characterization Of Saponins With Adjuvant Activity From Quillaja saponaria Molina Cortex, J. Immunol. 146(2):431-437 (Jan. 15, 1991).
Kensil, C.R. et al., "Structure/Function Relationship in Adjuvants from Quillaja saponaria Molina, in Vaccines 92, F. Brown et al. (ed.), 1992 [pp. 35-40].
Kimura, T. et al., Mechanisms of Toxicities of Some Detergents Added to a Diet and of the Ameliorating Effect of Dietary Fiber in the Rat, Journal of Nutrition Science Vitaminology 28:483-489 (1982).
Lee, W.A. et al., Intranasal Delivery of Proteins and Peptides, BioPharm, 30-37 (Apr. 1988).
Longenecker, J.P. et al., Effects of Sodium Taurodihydrofusidate on Nasal Absorption of Insulin in Sheep Journal of Pharmaceutical Sciences 76:351-355 (1987).
Maharaj, I. et al., "Immune Response of Mice to Inactivated Rabies Vaccine Administered Orally: Potentiation" by Quillaja saponin, Can. J. Microbiol. 32:414-420 (1986).
Maitani, Y. et al., Intranasal Administration of .beta.-Interferon in Rabbits, Drug Design and Delivery 1:65-70 (1986).
Martin, G.P. et al., Membrane Damage bv Bile Salts: The Protective Function of Phospholipids. Journal of Pharmaceutical Pharmacology 31:754-759 (1981).
McColm, A.A. et al., A comparison of saponin with other adjuvants for the potentiation of protective immunity by a killed Plasmodium yoelii vaccine in the mouse, Parasite Immunology 4:337-347 (1982).
Moore, J.A. et al., Delivery Systems for Recombinant Methionyl Human Growth, in Davis, S.S. et al., eds., Delivery Sytems for Peptide Drugs, Plenum Press, New York, pp. 317-329 (1986).
Moses, A.C. et al., Insulin Administered Intranasally as an Insulin-Bile Salt Aerosol Effectivenes and Reproducibility in Normal and Diabetic Subjects, Diabetes 32:1040-1047 (1983).
Pillion, D.J. et al., Systemic Absorption of Insulin Delivered Topically to the Rat Eye, Investigative Opthalmology & Visual Science 32:3021-3027 (1991).
Scott, M.T. et al., Adjuvant Activity of Saponin: Antigen Localization Studies, Int. Archs Allergy appl. Immun. 77:409-412 (1985).
White, A.C. et al. A Purified Saponin Acts As An Adjuvant For A T-Independent Antigen, in Atassi M.Z. ed., Immunobiology of Proteins and Peptides VI, Plenum Press, New York, pp. 207-210 (1991).
Whitmore, D.A. et al., Relative effects of different surfactants on intestinal absorption and the release of proteins and phospholipids from the tissue, Journal of Pharmaceutical Pharmacology 31:277-283 (1979).
Wu, J. et al., Saponin Adjuvant Enhancement Of Antigen-Specific Immune Responses To An Experimental HIV-1 Vaccine, J. Immunol. 148(5):1519-1525 (Mar. 1, 1992).
Pillion, Dennis J. et al., DS-1, a Modified Quillaja saponin, Enhances Ocular and Nasal Absorption of Insulin, Journal of Pharmaceutical Sciences 84(11):1276-1279 (Nov. 1995).
Copy of Supplementary European Search Report issued in corresponding European Application No. EP-93-91-6972, mailed Dec. 20, 1995.
Kensil Charlotte A.
Marciani Dante J.
Recchia Joanne
Soltysik Sean
Cambridge Biotech Corporation
Rollins John W.
LandOfFree
Drug delivery enhancement via modified saponins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Drug delivery enhancement via modified saponins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug delivery enhancement via modified saponins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1560083