Surgery – Respiratory method or device – Ozone or ion generation
Patent
1980-11-10
1982-08-31
Rosenbaum, C. Fred
Surgery
Respiratory method or device
Ozone or ion generation
424 19, A61M 700
Patent
active
043467091
ABSTRACT:
Erodible devices are disclosed for delivering a drug to an environment of use. The devices comprise a body sized and adapted for delivering the drug to the environment of use, which body comprises (1) a poly(orthoester) or a poly(orthocarbonate) having a repeating unit consisting of a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## wherein R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least one of the R.sub.2 or R.sub.3 bonded to the dioxycarbon through an oxygen covalent bond, (2) a beneficial drug, and (3) an erosion rate modifier. The devices are useful for delivering both locally and systemically acting drugs over a prolonged period of time. A composition of matter is also disclosed comprising the poly(orthoesters) or the poly(orthocarbonates) and an erosion rate modifier.
REFERENCES:
patent: 3867519 (1975-02-01), Michaels
patent: 4066747 (1978-01-01), Capozza
patent: 4070347 (1978-01-01), Schmitt
patent: 4093709 (1978-06-01), Choi et al.
patent: 4131648 (1978-12-01), Choi et al.
patent: 4138344 (1979-02-01), Choi et al.
ALZA Corporation
Mandell Edward L.
Rosenbaum C. Fred
Sabatine Paul L.
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