Drug delivery device especially for the delivery of progestins a

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424473, 424486, 424449, A61F 1300

Patent

active

060633956

ABSTRACT:
The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially a progestin or an estrogen, over a prolonged period of time, said device including a core which contains the therapeutically active agent, and a membrane encasing the core wherein said membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer which includes 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units.

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patent: 4957119 (1990-09-01), de Nijs
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patent: 5824736 (1998-10-01), Kobayashi et al.
Sun et al., "Effect of Polymer Composition...," 5 J. Controlled Release 69-78 (1987).
Ghannam et al., "Kinetics and Thermodynamics of Drug...," 12 Drug Dev. Ind. Pharm. 303-325 (1986).
Sun et al., "Kinetics and Thermodynamics of Drug...," 12 Drug Dev. Ind. Pharm. 327-348 (1986).

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