Drug delivery device, especially for the delivery of androgens

Details Drug delivery device, especially for the delivery of androgens Drug delivery device, especially for the delivery of androgens

1998-11-12

2000-09-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424473, 424486, 424449, A61F 1300

Patent

active

061174424

ABSTRACT:
The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially an androgen, over a prolonged period of time, said device including a core containing the therapeutically active agent, and a membrane encasing the core wherein the membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer which includes 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units.

REFERENCES:
patent: 3854480 (1974-12-01), Zaffaroni
patent: 4244949 (1981-01-01), Gupta
patent: 4957119 (1990-09-01), de Nijs
patent: 5088505 (1992-02-01), de Nijs
patent: 5150718 (1992-09-01), de Nijs
patent: 5733565 (1998-03-01), Moo-Young et al.
patent: 5824736 (1998-10-01), Kobayashi et al.
Sun et al, "Effect of Polymer Composition . . . ,"5 J. Controlled Release 69-78 (1987).
Ghannam et al., "Kinetics and Thermodynamics of Drug . . . ," 12 Drug Dev. Ind. Pharm. 303-325 (1986).
Sun et al., "Kinetics and Thermodynamics of Drug . . . ," 12 Drug. Dev. Ind. Pharm. 327-348 (1986).

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