Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2011-04-12
2011-04-12
Nutter, Nathan M (Department: 1765)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C525S191000, C525S240000, C525S241000
Reexamination Certificate
active
07923509
ABSTRACT:
A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X-(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
REFERENCES:
patent: 4276394 (1981-06-01), Kennedy et al.
patent: 4316973 (1982-02-01), Kennedy
patent: 4342849 (1982-08-01), Kennedy
patent: 4481323 (1984-11-01), Sterling
patent: 4910321 (1990-03-01), Kennedy et al.
patent: 4929683 (1990-05-01), Kennedy et al.
patent: 4946899 (1990-08-01), Kennedy et al.
patent: 5066730 (1991-11-01), Kennedy et al.
patent: 5100992 (1992-03-01), Cohn et al.
patent: 5122572 (1992-06-01), Kennedy et al.
patent: RE34640 (1994-06-01), Kennedy et al.
patent: 5616608 (1997-04-01), Kinsella et al.
patent: 5630844 (1997-05-01), Dogan et al.
patent: 5716981 (1998-02-01), Hunter et al.
patent: 5733925 (1998-03-01), Kunz et al.
patent: 5741331 (1998-04-01), Pinchuk
patent: 5879697 (1999-03-01), Ding et al.
patent: 5900246 (1999-05-01), Lambert
patent: 5968091 (1999-10-01), Pinchuk et al.
patent: 5980972 (1999-11-01), Ding
patent: 6028147 (2000-02-01), Ogawa et al.
patent: 6197240 (2001-03-01), Pinchuk
patent: 6303697 (2001-10-01), Yuan et al.
patent: 6368658 (2002-04-01), Schwarz et al.
patent: 6545097 (2003-04-01), Pinchuk et al.
patent: 6855770 (2005-02-01), Pinchuk et al.
patent: 0821973 (1998-04-01), None
patent: 002211137 (1981-07-01), None
patent: 002211135 (1990-11-01), None
patent: 002211136 (1994-07-01), None
patent: 10005345 (1998-01-01), None
patent: 10-151189 (1998-06-01), None
patent: 2000157627 (2000-06-01), None
patent: WO 00/62830 (2000-10-01), None
Gyor et al., “Polyisobutylene-Based Thermoplastic Elastomers. I. Synthesis and Characterization of Polystyrene-Polyisobutylene-Polystyrene Triblock Copolymers,” J.M.S. Pure Appl. Chem.., A31(12), pp. 2055-2065 (1994).
Pinchuk et al., “A New Family of Thermoplastic Elastomers for Ultra-Long Term Implant Based Upon a Backbone of Alternating Quaternary and Secondary Carbons,” 24thAnnual Meeting of the Society for Biomaterials, Apr. 22-26, 1998, San Diego, CA, p. 173.
Shinichi Terada et al., “Experimental Study of Ectopic-Free Tissue Transfer of Rabbit Epigastric Flap Using Small-Caliber Vascular Grafts,” Journal of Biomedical Materials Research, vol. 45, No. 1, Apr. 1999, pp. 28-355.
Ding Ni
Hashemi Sepideh
Kamath Kalpana
Pinchuk Leonard
Schwarz Marlene C.
Bonham David B.
Boston Scientific Scimed Inc.
Mayer & Williams PC
Nutter Nathan M
Park Keum J.
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