Drug delivery compositions

Details Drug delivery compositions Drug delivery compositions

1995-12-21

1998-04-28

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424426, 424428, 424430, 424434, 424435, 424436, 424437, 424464, 424469, 424499, 5147723, 514777, 514778, A61K 950, A61K 914, A61K 920, A61K 4736

Patent

active

057441669

ABSTRACT:
Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a pharmacologically active agent in a pharmaceutically acceptable carrier. The compositions in one embodiment permit transport of pharmacologically active compounds across mucosal membranes for systemic delivery. The polycationic polymer may be, for example, a polycationic carbohydrate such as a chitosan or a chitosan salt or derivative. The therapeutic agent a preferred embodiment is a vaccine or a nucleic acid, such as a gene or antisense oligonucleotide. The composition may be provided in different forms such as a solution, dispersion, powder or in the form of microspheres.

REFERENCES:
patent: 4946870 (1990-08-01), Partain, III et al.

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