Drug delivery collagen-impregnated synthetic vascular graft

Details Drug delivery collagen-impregnated synthetic vascular graft Drug delivery collagen-impregnated synthetic vascular graft

1992-04-30

1993-03-30

Isabella, David

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

623 66, 427 2, B61F 206

Patent

active

051979772

ABSTRACT:
A collagen impregnated vascular graft including drug materials complexed with the collagen to be released slowly from the graft following implant. The graft is a porous synthetic vascular graft substrate having collagen fixed to the graft substrate and cross-linking the collagen in situ to render the porous substrate blood-tight. The drug materials complexed with the collagen fibrils may include antithrombic agents, antibacterial, antimicrobial agents, antifungal agents and the like.

REFERENCES:
patent: 3272204 (1966-09-01), Artandi
patent: 3425418 (1969-02-01), Chvapil et al.
patent: 3928653 (1975-12-01), Dowell, Sr. et al.
patent: 4047252 (1977-09-01), Liebig et al.
patent: 4416028 (1983-11-01), Eriksson et al.
patent: 4842575 (1989-06-01), Hoffman, Jr. et al.

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