Drug delivery by multiple frequency phonophoresis

Details Drug delivery by multiple frequency phonophoresis Drug delivery by multiple frequency phonophoresis

1993-02-11

1993-12-07

Weiss, John G.

Surgery

Means for introducing or removing material from body for...

Treating material applied to or removed from external...

604 22, 128 241, 606 27, A61M 3500, A61B 1720

Patent

active

052679853

ABSTRACT:
The present invention provides a method and apparatus for enhancing the diffusion of a substance to a local area of material or tissue by providing ultrasonic energy to the substance and material in two or more distinct frequencies simultaneously. Each of the distinct frequencies of ultrasonic energy is chosen to enhance permeation of the substance through one or more diffusion rate-limiting sections of the material.

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T. J. Antich, "Phonoresis: The Principles of the Ultrasonic Driving Force and Efficacy in Treatment of Common Orthopaedic Diagnosis", The Journal of Orthopaedic and Sports Physical Therapy, vol. 4, No. 2, pp. 99-102.
Donald M. Skauen et al., "Phonophoresis," International Journal of Pharmaceutics, 20 (1984) 235-245.

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