Drug-containing protein-bonded liposome

Details Drug-containing protein-bonded liposome Drug-containing protein-bonded liposome

1992-05-22

1993-11-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 436829, 935 54, 530812, A61K 9127

Patent

active

052642216

ABSTRACT:
A drug-containing protein-bonded liposome comprising a liposome containing a drug and having maleimide residues on its surface, and a protein and residues of a compound having a polyalkylene glycol moiety, bonded via respective thiol groups to the maleimide residues.

REFERENCES:
patent: 4429008 (1984-01-01), Martin
patent: 5059421 (1991-10-01), Loughrey et al.
Allen et al BBA, 1066, p. 29, 1991.
Klibanov. FEBS 268, p. 235 1990.
Biochimica et Biophysica Acta, 1062, pp. 142-148, 1991, A. L. Klibanov, et al., "Activity of Amphipathic Poly(ethylene glycol) 5000 to Prolong the Circulation Time of Liposomes Depends on the Liposome Size and is Unfavorable for Immunoliposome Binding to Target".
FEBS Letters, vol. 284, No. 2, pp. 263-266, Jun., 1991, A. Mori, et al., "Influence of the Steric Barrier Activity of Amphipathic Poly(ethyleneglycol) and Ganglioside GM.sub.1 on the Circulation Time of Liposomes and on the Target Binding of Immunoliposomes in Vivo".
Nature, vol. 288, pp. 602-604, Dec. 11, 1980, L. D. Leserman, et al., "Targeting to Cells of Fluorescent Liposomes Covalently Coupled with Monoclonal Antibody or Protein A".
The Journal of Biological Chemistry, vol. 257, No. 1, pp. 286-288, Jan. 10, 1982, F. J. Martin, et al., "Irreversible Coupling of Immunoglobulin Fragments to Preformed Vesicles".
The Journal of Biological Chemistry, vol. 255, No. 17, pp. 8015-8018, Sep. 10, 1980, A. Huang, et al, "Monoclonal Antibody Covalently with Fatty Acid".
Cancer Research, vol. 43, pp. 5328-5334, Nov., 1983, Y. Hashimoto, et al., "Antitumor Effect of Actinomycin D Entrapped in Liposomes Bearing Subunits of Tumor-Specific Monoclonal Immunoblobulin M Antibody.sub.1 ".
Cancer Research, vol. 47, pp. 4471-4477, Aug. 15, 1987, H. Konno, et al., "Antitumor Effect of Adriamycin Entrapped in Liposomes Conjugated with Anti-Human Alpha-Fetoprotein Monoclonal Antibody.sub.1 ".
FEBS Letters, vol. 268, No. 1, pp. 235-237, Jul., 1990, A. L. Klibanov, et al., "Amphipathic Polyethyleneglycols Effectively Prolong the Circulation Time of Liposomes".
Biochimica et Biophysica Acta, 1061, pp. 56-64, 1991, T. M. Allen, et al., "Uptake of Liposomes by Cultured Mouse Bone Marrow Macrophages: Influence of Liposome Composition and Size".
Biochimica et Biophysica Acta, 1066, pp. 29-36, 1991, T. M. Allen, et al., "Liposomes Containing Synthetic Lipid Derivatives of Poly(ethylene glycol) Show Prolonged Circulation Half-Lives in Vivo".
World Patent Index Latest, No. 89-335876.

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