Drug-containing adhesive composite transdermal delivery device

Details Drug-containing adhesive composite transdermal delivery device Drug-containing adhesive composite transdermal delivery device

1995-10-17

1997-05-06

Krass, Frederick

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 424449, A61F 1300, A61F 1302

Patent

active

056268661

ABSTRACT:
A method for making a transdermal drug delivery device for heat sensitive and volatile drugs is disclosed. The device contains a drug-containing adhesive composite layer having an impermeable backing material laminated to the distal surface thereof and a proximal peelable impermeable backing material adapted for removal for administering a drug to the skin or mucosa laminated to the proximal surface thereof. The method comprising the steps of providing first and second adhesive laminates each comprising a drug permeable adhesive layer having laminated to one surface one of said backing materials and having the opposing surface exposed. The drug, in gelled form and optionally containing additives such as enhancers and preservatives, is extruded onto at least one exposed surface of the first or second adhesive laminate followed by laminating together the exposed surfaces of the first and second adhesive laminate such that the adhesive layers and gelled drug are combined to form the drug-containing adhesive composite layer having the distal and proximal surfaces covered by the respective backing materials. The adhesives used in making up the laminates may be the same or different provided the drug is compatible with the adhesive. The process is particularly adaptable to the formulation of nicotine-containing patches. Drug delivery devices made according to the disclosed method and a method of using these drug delivery devices are also described.

REFERENCES:
patent: 4597961 (1986-07-01), Etscorn
patent: 4715387 (1987-12-01), Rose
patent: 4915950 (1990-04-01), Miranda et al.
patent: 4920989 (1990-05-01), Rose et al.
patent: 4943435 (1990-07-01), Baker et al.
patent: 5016652 (1991-05-01), Rose et al.
patent: 5077104 (1991-12-01), Hunt et al.
patent: 5110599 (1992-05-01), Anhauser et al.
patent: 5254346 (1993-10-01), Tucker et al.

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