Drug conjugates

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07847119

ABSTRACT:
A compound having the formula Y-A-Z, wherein:A is a phenyl group which is unsubstituted or substituted;Y and Z are substituents at adjacent positions on ring A;Y represents:Z represents:and wherein the remaining variables are as defined in the specification.

REFERENCES:
patent: 3324140 (1967-06-01), Schorre et al.
patent: 3458563 (1969-07-01), Cragoe, Jr.
patent: 3600437 (1971-08-01), Marshall
patent: 4049665 (1977-09-01), Douglass
patent: 4258193 (1981-03-01), Fujii et al.
patent: 4324793 (1982-04-01), Hagen et al.
patent: 4396621 (1983-08-01), Bernasconi et al.
patent: 4493802 (1985-01-01), Jaedicke et al.
patent: 4505917 (1985-03-01), Menon et al.
patent: 4880935 (1989-11-01), Thorpe
patent: 4902826 (1990-02-01), Bauer et al.
patent: 5002967 (1991-03-01), Mueller et al.
patent: 5124441 (1992-06-01), Carlsson et al.
patent: 5137877 (1992-08-01), Kaneko et al.
patent: 5274184 (1993-12-01), Nagl et al.
patent: 5932731 (1999-08-01), Goda et al.
patent: 5936092 (1999-08-01), Shen et al.
patent: 6008321 (1999-12-01), Li et al.
patent: 6313150 (2001-11-01), Ohtsuka et al.
patent: 7282590 (2007-10-01), Ojima
patent: 2003/0100607 (2003-05-01), Tsukamoto et al.
patent: 5363336 (1978-06-01), None
Srogl et al. CAS Acession No. 1999:629460.
Ojima et al., “Tumor-Specific Novel Taxoid—Monoclonal Antibody Conjugates,” J. Med. Chem. 2002, 45:5620-5623.
Y. Ueda, “Novel Water Soluble Phosphate Prodrugs of Taxol® Possessing in Vivo Antitumor Activity”,Bioorganic&Medicinal Chemistry Letters, vol. 3, No. 8, pp. 1761-1766 (1993).
I. Ojima et al., “Syntheses and Structure—Activity Relationships of the Second-Generation Antitumor Taxoids: Exceptional Activity against Drug-Resistant Cancer Cells”,J. Med. Chem., vol. 39, No. 20, pp. 3889-3896 (1996).
M.P. Dillon et al. “Application of the ‘Trimethyl Lock’ to Ganciclovir, a Pro-Prodrug with Increased Oral Bioavailability”,Bioorganic&Medicinal Chemistry Letters, vol. 6, No. 14, pp. 1653-1656 (1996).
B. Wang et al., “Synthesis of a Novel Esterase-Sensitive Cyclic Prodrug System for Peptides that Utilizes a ‘Trimethyl Lock’-Facilitated Lactonization Reaction”,J. Org. Chem., vol. 62, No. 5, pp. 1363-1367 (1997).
I. Ojima et al., “Synthesis and Structure—Activity Relationships of New Second-Generation Taxoids”,Bioorg. Med. Chem. Lett., vol. 9, pp. 3423-3428 (1999).
R.B. Greenwald et al., “Drug Delivery Systems Based on Trimethyl Lock Lactonization: Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds”,J. Med. Chem., vol. 43, No. 3, pp. 475-487 (2000).
K. Achilles, “Coumarin Derivatives as Protease-Sensitive Prodrugs”,Arch. Pharm. Pharm. Med. Chem., vol. 334, pp. 209-215 (2001).
M.R. Vredenburg et al., “Effects of Orally Active Taxanes on P-Glycoprotein Modulation and Colon and Breast Carcinoma Drug Resistance”,Journal of the National Cancer Institute, vol. 93, No. 16, pp. 1234-1245 (2001).
Block et al., Antithrombotic Organosulfur Compounds from Garlic: Structural, Mechanistic, and Synthetic Studies, J. Am. Chem. Soc., vol. 108, pp. 7045-7055 (1986).
Bressler et al., “Identification of disulfides from the biodegradation of dibenzothiophene,” Applied and Environmental Microbiology, vol. 17(11), pp. 5084-5093 (2001).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Drug conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drug conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug conjugates will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4220020

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.