Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1985-12-16
1988-08-16
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 85, 424450, 424457, 424 9, A61K 4900, A61K 3900, A61K 922
Patent
active
047643595
ABSTRACT:
Drug compositions formed as individual units, a multitude of which are employed as one or more doses, to reduce or aleviate cancer in a living being by targeting to and destroying cancer cells. In a preferred form, each drug unit is formed of an antibody, such as a monoclonal antibody targeted to a specific type of antigen, such as defined by a specific form of cancer, which antibody is united with or bonded to a white blood cell such as a macrophage or lymphocyte, preferably one which has been treated or activated with an immune system activator of a class referred to as lymphokines. One of such activators which may be so employed, is interleukin-2, which, in one embodiment, forms part of the drug unit. The drug unit may also include a microcapsule containing one or more of such lymphokine activated killer cells encapsulated therein and releasable therefrom, preferably after the drug unit has been targeted to a cancer cell or tumor by the antibody attached thereto. In a particular form, both the antibody and one or more of the white blood cells, lymphocytes or macrophages, cooperate in attacking the cancer cell or cells at the targeted site and the procedure progresses as cancer cells are destroyed exposing other cancer cells to additional drug units which feed to the cancer site in blood flow, in a manner to totally destroy the tumor or put into regression.
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