Drug composition antagonistic to both PGD 2 /TXA 2 receptors

Details Drug composition antagonistic to both PGD 2 /TXA 2 receptors Drug composition antagonistic to both PGD 2 /TXA 2 receptors

2006-08-01

2006-08-01

Zucker, Paul A. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S414000, C514S422000, C514S438000, C514S441000, C514S443000, C514S444000, C514S445000, C514S465000, C544S060000, C548S465000, C548S562000, C549S049000, C549S051000, C549S059000, C549S060000, C549S078000, C549S080000, C549S469000

Reexamination Certificate

active

07084136

ABSTRACT:
A compound of the formula (I):wherein A is alkylene optionally having an unsaturated bond; R is —C(═O)—R1; R1is hydroxy or the like; m is 0 or 1; p is 0 or 1; X1and X3are each independently optionally substituted aryl or optionally substituted heteroaryl or the like; X2is a bond, —CH2—, —S—, —SO2—, —CH2—O—, —O—CH2—, —CH2—S—, —S—CH2—, or the like; X4is —CH2—, —CH2—CH2—, —C(═O)—, or the like, having a dual antagonistic activity against both a thromboxane A2receptor and a prostaglandin D2receptor is found.

REFERENCES:
patent: 6172113 (2001-01-01), Ohtani et al.
patent: 6225336 (2001-05-01), Honma
patent: 42 25 488 (1994-02-01), None
patent: 92/09573 (1992-06-01), None
patent: 97/00853 (1997-01-01), None
patent: 97/853 (1997-01-01), None
patent: 99/15502 (1999-04-01), None
T. Tsuri et al., “Bicyclo[2.2.1.]heptane and 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives: Orally Active, Potent, and Selective Prostaglandin D2Receptor Antagonists”, Journal of Medicinal Chemistry, vol. 40, pp. 3504-3507, 1997.
W. Skuballa et al., “Synthesis of a New Chemically and Metabolically Stable Prostacyclin Analogue with High and Long-Lasting Oral Activity”, Journal of Medicinal Chemistry, vol. 29, No. 3, pp. 313-315, 1986.
P. Deicke et al., “Synthesis of New Metabolically Stabilized TXA2/PGH2-Receptor Antagonists and Their Biological Properties”, Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 9, pp. 1069-1072, 1992.
S. Sturzebecher et al., “Pharmacological Profile of a Novel Carbacyclin Derivative with High Metabolic Stability and Oral Activity in the Rat”, Prostaglandins, vol. 31, pp. 95-109, 1986.
M. Hildebrand et al., “Pharmacokinetics of Iloprost and Cicaprost in Mice”, Prostaglandins, vol. 44, pp. 431-442, 1992.
U. Klar et al., “Novel Prostanoid Thromboxane A2Antagonists”, Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 12, pp. 1219-1224, 1995.

Affiliated with

Also associated with

Rating

Drug composition antagonistic to both PGD 2 /TXA 2 receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drug composition antagonistic to both PGD 2 /TXA 2 receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug composition antagonistic to both PGD 2 /TXA 2 receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3698073