Drug composition and process for preparing the same

Details Drug composition and process for preparing the same Drug composition and process for preparing the same

1996-01-25

1998-09-29

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 55, 514 56, 536 20, 536 21, 536123, 5361231, 424418, A61K 31715, A61K 31725, A61K 3173

Patent

active

058146210

ABSTRACT:
A drug composition comprising a mucopolysaccharide (also referred in the art as a glycosaminoglycan) and a drug which is scarcely soluble in water but soluble in a water-miscible organic solvent, wherein fine crystals or fine particles of the drug is attached on or between the particles of a mucopolysaccharide, and a process for preparing the same. The drug composition of the present invention exhibits greatly improved solubility and a dissolution rate of the drug, and thus greatly improve the drug's bioavailability.

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patent: 4533549 (1985-08-01), Lasker
patent: 4686288 (1987-08-01), Lormeau et al.
patent: 4925677 (1990-05-01), Feijen
patent: 4937270 (1990-06-01), Hamilton et al.
patent: 5143724 (1992-09-01), Leshchiner et al.
patent: 5185152 (1993-02-01), Peyman
patent: 5246698 (1993-09-01), Leshchiner et al.
Brown et al. International Journal of Tissue Reactions, vol. 17(4): 133-140, (1995) Absract only.
Miura et al. Front. New Horiz. Amino Acid Res., Proc. Bienn. Int. Conf., 1st, pp. 385-389, (1992) Abstract only.
Gurny et al. J. Controlled Release, vol. 6:367-373, (1987) Abstract only.

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