Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-03-01
1995-12-12
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514179, 514420, 514458, 514560, 514570, 514650, A61K 3173, A61K 3156, A61K 3140, A61K 31355
Patent
active
054749891
ABSTRACT:
The present invention relates to a drug composition in which the solubility and the dissolution rate of a drug having low water solubility are improved by incoroprating therein a low molecular weight chitosan in an amount of from 0.2 to 10 parts by weight per one part by weight of the poorly water-soluble drug. As the low molecular weight chitosan, those having a weight average molecular weight in the range from 500 to 50,000 and soluble in water were employed. This drug composition is prepared by mixing the components intimately so as to obtain a homogeneous dispersion of the low molecular weight chitosan with the mass of the composition.
The drug composition according to the invention can be worked up into various preparation forms, such as, granules etc., as medicaments for administration to living organisms in which the bioabsorptivity and biouptake are improved.
REFERENCES:
patent: 4946870 (1990-08-01), Partain, III et al.
Chemical Abstracts (103: 92752t) 1985.
Chemical Abstracts (106: 182672h) 1987.
Chemical Abstracts (109: 197081a) 1988.
Hashimoto Masanori
Imai Teruko
Otagiri Masaki
Henley III Raymond
Kurita Water Industries Ltd.
Weddington Kevin E.
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