Drug bonded prosthesis and process for producing same

Details Drug bonded prosthesis and process for producing same Drug bonded prosthesis and process for producing same

1988-07-18

1989-11-07

Kight, John

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

128334R, 623 1, 623 11, 623 12, 623 66, 521 30, A61F 100, A61F 124

Patent

active

048791350

ABSTRACT:
There is disclosed an improved prosthesis coated, respectively, with an anionic surfactant, a drug such as an antibiotic and/or antithrombotic agent. Optionally, the coated prosthesis may be treated with an ion exchange compound, to remove un-drug bound anionic surfactant. The drug is bound directly to the surfactant coated prosthesis.

REFERENCES:
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patent: 4581028 (1986-04-01), Fox, Jr. et al.
patent: 4612337 (1986-09-01), Fox, Jr. et al.
patent: 4740382 (1988-04-01), Greco et al.
Jagpal, R., Greco, R. S.; "Studies of a Graphite-Benzalkoniumoxacillin Surface", Amer. Surg. 45:774-779, 1979.
Greco, R. S., Harvey, R. A., Henry, R., Prahlad, A.: "Prevention of Graft Infection by Antibiotic Bonding," Surg. Forum XXXI: 29-30, 1980.
Henry, R., Harvey, R. A., Greco, R. S.: "Antibiotic Bonding to Vascular Prostheses", J. Thorac. Cardiov. Surg. 82:272-277, 1981.
Harvey, R. A., Greco, R. S.: "The Non-Covalent Bonding of Antibiotics to a Polytetrafluoroethylene Graft", Ann. Surg. 194:642-647, 1981.
Prahlad, A., Harvey, R. A., Greco, R. S.: "Diffusion of Antibiotics from a Polytetrafluoroethylene (PTFE) Surface", Amer. Surg. 47:515-518, 1981.
Greco, R. S., Harvey, R. A.: "The Role of Antibiotic Bonding in the Prevention of Vascular Prosthetic Infections", Ann. Surg. 195:168-171, 1982.
Harvey, R. A., Alcid, D. V., Greco, R. S.: "Antibiotic Bonding to Polytetrafluoroethylene with Tridodecylmethylammonium Chloride", Surg. 92:504-512, 1982.
Greco, R. S., Harvey, R. A., Smilow, P. C., Tesoriero, J. V.: "Prevention of Vascular Prosthetic Infection by a Benzalkoniumoxacillin Bonded Polytetrafluoroethylene Graft", Surg. Gynec. Obstet. 155:28-32, 1982.
Trooskin, S. Z., Harvey, R. A., Greco, R. S.: "Prevention of Catheter Sepsis by Antibiotic Bonding", Surg. Forum 34:132-133, 1983.
Greco, R. S., Tesoriero, J. V., Smilow, P. C., Harvey, R. A.: "Light and Electron Microscopic Studies of an Antibiotic Bonded Vascular Graft", J. Cardiov. Surg. 25:489-497, 1984.
Harvey, R. A., Tesoriero, J. V., Greco, R. S.: "The Non-Covalent Bonding of Penicillin and Cefazolin to Dacron", Amer. J. Surg. 147:205-209, 1984.
Greco, R. S., Harvey, R. A.: "The Biochemical Bonding of Cefoxitin to a Microporous Polytetrafluorethylene Surface", J. Surg. Res. 36A:237-243, 1984.
Donetz, A. P., Harvey, R. A., Greco, R. S.: "The Stability of Antibiotics Bound to Polytetrafluoroethylene with Cationic Surfactants", J. Clin. Microbiol. 19:1-3, 1984.
Greco, R. S., Donetz, A. P., Harvey, R. A.: "The Application of Antibiotic Bonding to the Treatment of Established Vacular Prosthetic Infection", Arch. Surg. 120(1):71-75, 1985.
Trooskin, S. Z., Donetz, A. P., Harvey, R. A., Greco, R. S.: "Prevention of Catheter Sepsis by Antibiotic Bonding", Surgery May 97(5) 547-551, 1985.
Trooskin, S. Z., Harvey, R. A., Greco, R. S., Donetz, A. P.: "Antibiotic Bonded Chronic Peritoneal Dialysis Catheters", Europ. Surg. Res.; Clin. Exper. Surg. XX Congress Europ. Soc.Surg. Res.; Rotterdam, The Netherlands, p. 2, May 1985.
Trooskin, S. Z., Harvey, R. A., Donetz, A. P., Baxter, J., Greco, R. S.: "Infection Resistant Continuous Peritoneal Dialysis Catheters", Nephron (In Press).
Trooskin, S. Z., Harvey, R. A., Donetz, A. P., Greco, R. S.: "Application of Antibiotic Bonding to CAPD Catheters", Frontiers in Peritoneal Dialysis 157-160, 1986.
Trooskin, S. Z. Harvey, R. A., Kahn, M., Lennard, T. W. J., Greco, R. S.: "Results of a Prospective Clinical Trial of Antibiotic Bonded Catheters for Continuous Ambulatory Peritoneal Dialysis (CAPD)".
Harvey, R. A., Greco, R. S.: "Antibiotic Bonding to Vascular Prostheses"

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