Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Patent
1996-11-15
1999-02-09
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
530350, 530352, 514 12, A61K 3843, A61K 3816, C07K 100
Patent
active
058690433
ABSTRACT:
This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein CSBP.beta., to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
REFERENCES:
patent: 5663313 (1997-09-01), Hawkins et al.
MPsrch amino acid sequence alignment search, Nov. 1997.
Arai, K. et al., "Cytokines: Coordinators of Immune and Inflammatory Responses", Annu. Rev. Biochem., 59: 783-836, 1990.
Lee, J.C. et al., "Inhibition of Monocyte IL-1 Production by the Anit-Inflammatory Compound, SK&F 86002", Int. J. Immunopharmac., 10(7): 835-843, 1988.
Lee, J.C. et al., "Effect of SK & F86002 on cytokine production by human monocytes", Agents and Actions, 27: 3-4, 1989.
Lee, J.C. et al., "Inhibition of Human Monocyte IL-1 Production by SK&F 86002", Int. J. Immunotherapy VI(1): 1-12, 1990.
Lee, J.C. et al., "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis", Nature, 372:22-29, Dec. 1994.
McLaughlin M.M., et al., "Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase", J. Biol. Chem., 271(14): 8488-8492, 1996.
Kinase-3, a Novel Substrate of CSBP p. 38 MAP Kinase, J. Biol. Chem. 271(14):8488-8492, 1996.
Kumar, S. et al., "Human Mitogen-activated Protien Kinase CSP1, but No. CSPB2, Complements a hog1 Deletion in Yeast", J. Biol. Chem., 270(49): 29043-29046, 1995.
Gaber, R.F. et al., "The Yeast Gene ERG6 Is Required for Normal Membrane Function but Is Not Essential for Biosynthesis of the Cell-Cycle-Sparking Sterol", Molec. and Cellular Biol., (9)8: 3447-3456, 1989.
Marshall, C.J., "MAP kinase kinase kinase, MAP kinase kinase and MAP kinase", Current Opinion, Genetics and Development, 4: 82-89, 1994.
Cano, E. et al., "Parallel signal processing among mammalian MAPKs", Elsevier Science Ltd., TIBS 20: 117-122, 1995.
Zervos, A.S. et al., "Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylase Max protein", Proc. Natl. Acad. Sci., 92: 10531-10534, 1995.
Jiang, Y. et al., "Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38.beta.)", J. Biol. Chem., 271(30): 17920-17926, 1996.
Lechner, C. et al., "ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation", Cell Biology, 93: 4355-4359, 1996.
Mullis, K. et al. "Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction", Methods in Enzymol., 155(21): 335-350, 1987.
McHale, M.M. et al., "Expression of Human Recombinant cAMP Phosphodiesterase Isozyme IV Reverses Growth Arrest Phenotypes in Phosphodiesterase-Deficient Yeast", Molec. Pharmacol., 39: 109-113, 1990.
Han, J. et al., "A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells", Science, 265: 808-811, 1994.
Freshney, N.W. et al., "Interleukin-1 Activates a Novel Protein Kinase Cascade That Results in the Phosphorylation of Hsp27", Cell, 78: 1039-1049, 1994.
Brewster, J.L. et al. "An Osmoesensing Signal Transduction Pathway in Yeast", Science, 259: 1760-1763, 1993.
Rouse, J. et al., "A Novel Kinase Cascade Triggered by Stress and Heat Shock That Stimulates Kinase-2 and Phosphorylation of the Small Heat Shock Proteins", Cell, 78: 1027-1037, 1994.
Mertens, S. et al., "SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases", FEBS Letters, 383: 273-276, 1996.
McDonnell Peter Colon
Young Peter Ronald
Eisenschenk Frank C.
Hecht Elizabeth J.
King William T.
Nolan Patrick J.
SmithKline Beecham Corporation
LandOfFree
Drug binding protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Drug binding protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug binding protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1946639