Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-12-30
1998-12-22
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 55, 514 56, 514 57, 514 59, 514 62, 514882, 514925, 514926, 514927, A61K 31715, A61K 3173, A61K 31725, A61K 3170
Patent
active
058520040
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to the use of polymers or biopolymers for the preparation of a drug for the treatment of lesions of all origins affecting the digestive tract from the buccal cavity to the anal extremity in human or veterinary medicine.
It also relates to a composition containing these polymers and intended for such a treatment.
BACKGROUND
The synthesis of CMDBS polymers (dextrans substituted by carboxymethyl, benzylamine and sulfonate) has been described in French Patent 2 461 724 and U.S. Pat. No. 4,740,594. Some of these polymers mimic heparin and may be used as plasma heparin replacement products, thanks to their anticoagulant and anticomplement properties.
Some of these CMDBS polymers mimic another property of heparin consisting of a stabilization, protection and potentialization of the in vitro biological activity of the growth factors of the FGF family (Tardieu and coll., Journal of Cellular Physiology, 1992, 150 pp. 194 to 203).
French Patent 2 644.066 describes the use of certain CMDBSs associated with FGFs for healing the skin and the cornea. Experiments have been conducted by provoking a cutaneous wound with the help of a hollow punch 6 mm in diameter in the rat. In this example, the CMDBS associated with the FGF 2 makes it possible to obtain a definite effect on the speed and the quality of skin repair.
Another biopolymer, dextran sulfate, has also been advanced in association with FGFS, as a stabilizer and protector, in Japanese Patent No. 13890. Dextran sulfate, moreover, is widely used in skin healing ointments and creams as well as in collyrium compositions, but, to the knowledge of the applicant, has no reported effect on the healing and regeneration of muscular lesions.
Another agent, sucrose sulfate ester and its aluminum salt, sucralfate, are products described and used, on their own or associated with FGFs, as agents in the treatment of ulcers and lesions of the digestive tract (U.S. Pat. No. 3.432.489 ) and in different pharmaceutical associations and compositions described in a series of patents (U.S. Pat. Nos. 4,975,281, 4,885,281, 5,013,557, 5,164,379, 5,196,405, 5,240,710 and Danish Patents 102488 and 505588).
The tissues of the digestive tract are particularly rich in growth factors and several authors have described the presence and/or action of FGFs and beta TGFs in/on enterocyte cells or the healing action of these factors in lesions of tissues of the digestive tract as well as the presence or the action of growth factors presenting an affinity for heparin or heparan such as AB or BB PDGFs or Hepatocyte Growth Factor (Lemoine N R; Leung H Y; Gullick W J; Growth Factors in the Gastrointestinal tract ; Gut 1992, 33, pp. 1297 to 1300; Di Gulietta A, Hervada T; Nardy R V; LESH C A: Effect of platelet derived growth factor BB on indomethacin-induced gastric lesions in rats; Scand. J. Gastroenterol. 1992, 27, pp. 673 to 676; Tajagascu M and coll. Hepatocyte growth factor induces mitogenic reaction to the rabbit gastric epithelial cells in primary culture; Biochem. and Biophys. Res. Comm. 1993, 191; 528-534; Mustoe and Coll. Differential acceleration of healing of surgical incisions in the rabbit gastrointestinal tract by platelet derived growth factor and transforming growth factor beta; Surgery 1990, 108, pp. 324 to 330; Katayama M; Kan M: Heparin-binding (fibroblast) growth factors are potential autocrine regulators of oesophageal epithelial cell proliferation, In Vitro Cell. Dev. Biol. 1991, 27, pp.533 to 541).
It thus emerges from an analysis of the state of the prior art that polymers have already been used in association with growth factors on certain lesions of a very particular type of tissue, namely cutaneous tissue.
In view of the unpredictable nature of the therapeutic effects of a given molecule, it was not clear wether these polymers could have an effect on tissues other than those of the skin.
It is, in fact, well known that the different tissues of the human or animal body present structural and functional specific features making it i
REFERENCES:
patent: 5401721 (1995-03-01), Folkman et al.
CA 119:364, Morere et al., 1992.
Barritault Denis
Caruelle Jean-Pierre
Meddahi Anne
Jordan Kimberly
Societe Valbiofrance
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