Drug activation by radiation

Details Drug activation by radiation Drug activation by radiation

1978-04-28

1980-05-13

Padgett, Benjamin R.

Surgery

Truss

Perineal

424 1, 424 15, 424 2, 424 9, A61K 2900, A61B 1000

Patent

active

042023238

ABSTRACT:
A method of selectively causing drug activation within a living body which comprises administering to a living body a polyamino arylmethylnitrile capable of undergoing controlled cleavage to form a polyaminoaryl methyl ion and/or a free cyanide ion, the drug also being soluble in the body serum so that it is capable of passing via oral, intramuscular or intra-peritoneal administration into a body, and then subjecting a localized area of said body to radiation capable of causing cleavage of the cyanide ion from the drug precursor, the resulting ions acting to sensitize the localized area to radiation.

REFERENCES:
patent: 4106488 (1978-08-01), Gordon

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