Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-05-02
2006-05-02
Andres, Janet (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S070100, C435S069500, C435S069700, C435S320100, C435S325000, C536S023100, C536S023400, C536S024300, C424S185100, C424S192100
Reexamination Certificate
active
07037676
ABSTRACT:
The present invention provides novel polynucleotides encodingDrosophilaDmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.
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Bowen Michael A.
Carroll Pamela M.
Chen Jian
Ramanathan Chandra S.
Xiao Hong
Andres Janet
Bristol-Myers Squibb
D'Amico Stephen C.
Klein Christopher A.
Seharaseyon Jegatheesan
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