Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Reexamination Certificate
2007-08-07
2007-08-07
Bertoglio, Valarie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
C800S009000, C800S010000
Reexamination Certificate
active
10469356
ABSTRACT:
Provided is a specialDrosophilastrain having a Bradeion gene artificially incorporated therein to exclusively express the gene in the compound eyes and thus to exhibit rough eye. TheDrosophilastrain has the following properties:(a) a human-derived Bradeion gene has been transferred in the strain to express the human-derived protein Bradeion in the compound eyes from the developmental period;(b) the compound eyes show morphological abnormality due to the expression of Bradeion; and(c) the morphological abnormality occurring in the compound eyes is multiplied according to the number of transferred Bradeion genes.
REFERENCES:
patent: 2000-139470 (2000-05-01), None
Kramer et al. (2003) GAL4 causes developmental defects and apoptosis when expressed in the developing eye of Drosophila melanogaster Genetics and Molecular Research, 2:43-47.
Tanka et al. (2001) Characterization of Tissue- and Cell-Type-Specific Expression of a Novel Human Septin Family Gene, Bradeion; Biochemical and Biophysical Communications. 286: 547-553.
http://flystocks.bio.indiana.edu/Fly—Work/culturing.htm (2006) pp. 1-5.
Jackson, “Polyglutamine-Expanded Human Huntingtin Transgenes Induce Degeneration of Drosophila Photoreceptor Neurons”, Neuron, vol. 21, 633-642, Sep. 1998.
Brand et al. “Targeted gene expression as a means of altering cell fates and generating dominant phenotypes”, Development 188, 401-415 (1993).
Yamaguchi et al., “Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc,”Oncogene, 1999, pp. 6767-6775, vol. 18, Stockton Press, UK.
Hirose et al., “Ectopic expression of DREF Induces DNA Synthesis, Apoptosis, and Unusual Morphogenesis in the Drosophila Eye Imaginal Disc: Possible Intereaction with Polycomb and trithorax Group Proteins,”Molecular and Cellular Biology, Nov. 2001, pp. 7231-7242, vol. 21, American Society for Microbiology.
Tanaka Manami
Yamaguchi Masamitsu
Bertoglio Valarie
National Institute of Advanced Industrial Science and Technology
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