Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-04-29
2008-04-29
Kemmerer, Elizabeth (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S348000, C435S325000, C530S350000, C530S328000
Reexamination Certificate
active
07364866
ABSTRACT:
The present invention providesDrosophila melanogasterGPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention also provides methods for the identification of homologs in other species and of DmGPCR agonists/antagonists useful as potential insecticides. The invention further provides methods for binding a DmGPCR, methods for identifying modulators of DmGPCR expression and activity, methods for controlling a population of insects with a DmGPCR antibody, a DmGPCR antisense polynucleotide, a DmGPCR binding partner or modulator, and methods of preventing or treating a disease or condition associated with an ectoparasite. Specifically, this invention discloses the matching of the orphanDrosophiladrotachykinin, droleucokinin, and drostatin-C receptors with their cognate peptide ligands.
REFERENCES:
patent: 4343940 (1982-08-01), Kreighbaum et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4447608 (1984-05-01), Jones et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4757072 (1988-07-01), Kabbe et al.
patent: 4879236 (1989-11-01), Smith et al.
patent: 5217999 (1993-06-01), Levitzki et al.
patent: 5302606 (1994-04-01), Spada et al.
patent: 5316553 (1994-05-01), Kaul et al.
patent: 5330992 (1994-07-01), Eissenstat et al.
patent: 5585277 (1996-12-01), Bowie et al.
patent: 5753615 (1998-05-01), Thorpe et al.
patent: 5880141 (1999-03-01), Tang et al.
patent: 6703491 (2004-03-01), Homburger et al.
patent: WO01/70980 (2001-09-01), None
patent: WO01/70981 (2001-09-01), None
patent: WO01/71042 (2001-09-01), None
Wells. 1990. Biochemistry 29:8509-8517.
Ngo et al. 1994. in The Protein Folding Problem and Tertiary Structure Prediction. pp. 492-495.
Schoneberg et al. 2004. Pharmacology and Therapeutics 104:173-206.
Li et al. 1991. EMBO J. 10:3221-3229.
Garcynski, et al., “Characterization of a functional neuropeptide F receptor fromDrosophila melanogaster,” Peptides (2002) 23:773-780.
Holmes, et al., “Cloning and transcriptional expression of leucokinin-like peptide receptor from the Southern cattle tick,Boophilus microplus(Acari:lxodidae),” Insect Mol. Biol. (2000) 9:457-465.
Kramer, et al., “Identification of an allatostatin from the tobacco hornwormManduca sexta,” Proc. Natl. Acad. Sci. USA (1991) 88:9458-9462.
Kubiak, et al., “Cloning and functional expression of the firstDrosophila melanogastersulfakinin receptor DSK-R1,” Biochem. Biophys. Res. Comm. (2002) 291:313-320.
Larsen, et al., “Type A allatostatinsfromDrosophila melanogasterandDiplotera punctataactivate twoDrosophila allatostatinreceptors, DAR-1 and DAR-2, expressed in CHO cells,” Biochem. Biophys. Res. Comm. (2001) 286:895-901.
Nichols, “Isolation and expression of theDrosophila drosufakininneural peptide gene product DSK-I,”0 Mol. Cell. Neurosci. (1992) 3:342-347.
O'Donnell, et al., “Hormonally controlled chloride movement acrossDrosophilatubules is via ion channels in stellate cells,” Am. J. Physiol. (1998) 43:R1039-R1049.
Price et al. “Drosophila melanogasterflatline encodes a myotropin orthologue toManduca sexta allatostatin,” Peptides (2002) 23:787-794.
Siviter, et al., “Expression and functional characterization of aDrosophilaneuropeptide precursor with homology to mammalian preprotachykinin A,” J. Biol. Chem. (2000) 275:23273-23280.
Staubli, et al., “Molecular identification of the insect adipokinetic hormone receptors,” Proc. Natl. Acad. SCi. USA (2002) 99:3446-3451.
Williamson, et al., “Molecular cloning, genomic organization, and expression of a C-type (Manduca sexta-type) allatostatin preprohormone fromDrosophila melanogaster,” Biochem. Biophys. Res. Comm. (2001) 282-124-130.
Stapleton, et al., “ADrosophilafull-length cDNA resource,” Genome Biol. (2002) 3:1-8.
Cazzamali, et al., “Molecular cloning and functional expression of aDrosophila corazoninreceptor,” Biochem. Biophys. Res. Comm. (2002) 298:31-36.
Mertens, et al., “ Characterization of the short neuropeptide F receptor fromDrosophila melanogaster,” Biochem. Biophys. Res. Comm. (2002) 1140-1148.
Park et al., “Identification of G protein-coupled receptors forDrosophilaPRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution,” Proc. Natl. Acad. Sci. USA (2002) 99:11423-11428.
Kreikenkamp et al., “Functional annotation of two orphan G-protein-coupled receptors, drostar1 and -2, fromDrosophila melanogasterand their ligands by reverse pharmacology,” J. Biol. Chem. (2002) 277:39937-39943.
Radford, et al., “Systematic G-protein-coupled receptor analysis inDrosophila melanogasteridentifies a leucokinin receptor with novel roles,” J. Biol. Chem. (2002) 277:38810-38817.
Cazzamali et al., “Molecular cloning and functional expression of the first insect FMRFamid receptor,”PNAS(2002) 99(19):12073-12078.
Howard et al., “Orphan G-protein-coupled receptors and natural ligand discovery,”Trends Pharmacol Sci(2001) 22(3):132-140.
Mickle et al., “Genotype-phenotype relationships in cystic fibrosis,”Med Clin North Am(2000) 84(3):597-607.
Skolnick et al., “From genes to protein structure and function: novel applications of computational approaches in the genomic era,”Tends Biotechnol(2000) 18(1):34-9.
Voet et al.Biochemistry, John Wiley & Sons, New York (1990), pp. 126-129 and pp. 228-234.
Yan et al., “Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors,”Science(2000) 290(549I):523-527.
Allen et al., “Modulation of CD4 by Suramin”,Clin. Exp. Immunol., 1993, vol. 91, pp. 141-156.
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,”Nucl. Acids Res.,1997, 25(17), 3389-3402.
Altschul et al., “Basic Local Alignment Search Tool,”J. Mol. Biol., 1990, 215, 403-410.
Anafi et al., “Tyrphostin-Induced Inhibition of p210ber-ablTyrosine Kinase Activity Induces K562 to Differentiate”,Blood, 1993, vol. 82, No. 12, pp. 3524-3529.
Anderson, W. F., “Human gene therapy,”Science, 1992, 256, 808-813.
Aukrust et al., “Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients with Unstable Angina. Possible Reflection of T Lymphocyte and Platelet Involvement in the Pathogenesis of Acute Coronary Syndromes”,Circulation, 1999, vol. 100, pp. 614-620.
Ausubel, et al. (Eds.), “Chapter 6, Screening of recombinant DNA libraries,”Current Protocols in Molecular Biology, 1994, John Wiley & Sons, 6.0.1-6.4.10.
Baindur et al.,“Selective fluorescent ligands for pharmacological receptors,”Drug Dev. Res., 1994, 33, 373-398.
Baker et al., “Induction of Acetylcholine Receptor Clustering by Native Polystyrene Beads. Implication of an Endogenous Muscle-derived Signalling System”,J. Cell Sci., 1992, vol. 102, pp. 543-555.
Benoist et al., “In vivo sequence requirements of the SV40 early promoter region,”Nature, 1981, 290, 304-310.
Bertino,Cancer Res., “Toward Improved Selectivity in Cancer Chemotherapy: The Richard and Hinda Rosenthal Foundation Award Lecture”, 1979, vol. 3, pp. 293-304.
Bilder et al., “Tyrphostins Inhibit PDGF-induced DNA Synthesis and Associated Early Events in Smooth Muscle Cells”,Amer. Physiol. Soc., 1991, pp. 6363-6143:C721-C730.
Birgul, N. et al., “Reverse physiology inDrosphila: Identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family”,The EMBO Journal, 1999, 18(21), 5892-5900.
Bohm, S. K., et al., “Regulatory mechanisms that modulate signalling by G-protein couple
Kubiak Teresa M.
Larsen Martha J.
Lowery David E.
Smith Valdin G.
Kemmerer Elizabeth
Pepper Hamilton LLP
Pharmacia & Upjohn Company
Shafer Shulamith H
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