Drosophila cell lines expressing genes encoding MHC class I anti

Details Drosophila cell lines expressing genes encoding MHC class I anti Drosophila cell lines expressing genes encoding MHC class I anti

1992-02-19

1994-05-24

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352401, 4353201, C12N 1500, C12N 500

Patent

active

053148134

ABSTRACT:
The present invention relates to a rational, elegant means of producing, loading and using Class I molecules to specifically activate CD8 cells in vitro, and their therapeutic applications in the treatment of a variety of conditions, including cancer, tumors or neoplasias, as well as viral, retroviral, autoimmune, and autoimmune-type diseases. The present invention also relates to vectors, cell lines, recombinant DNA molecules encoding human .beta.2 microglobulin or Class I MHC molecules in soluble and insoluble form, and methods of producing same.

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