Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-10-30
2007-10-30
Saoud, Christine J. (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S402000
Reexamination Certificate
active
11142736
ABSTRACT:
The present invention provides novel polynucleotides encodingDrosophilaDmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding twoDrosophilaDmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifyingDrosophilaor cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.
REFERENCES:
patent: 7037676 (2006-05-01), Carroll et al.
patent: WO0055178 (2000-09-01), None
patent: WO0076308 (2000-12-01), None
patent: WO0171042 (2001-09-01), None
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Wells, Aditivity of Mutational Effects in Proteins, 1990, Biochemistry, vol. 26, No. 37, pp. 8509-8517.
NCBI Entrez Accession No. AA201867 (gi:1797632), Berkeley Dropsophila Genome Project, entry created Jan. 24, 1997.
NCBI Entrez Accession No. AAF58848 (gi:7303801), Adams, et al., Feb. 14, 2003.
NCBI Entrez Accession No. AAM51093 (gi:21430830), Stapleton, et al., Jun. 16, 2002.
NCBI Entrez Accession No. AAM76710 (gi:21717646), Moreno, et al., Aug. 14, 2002.
Igaki et al. (2002) European Mol. Biol. Organization 3009-3018.
Moreno et al. (2002) Current Biology 12:1263-1268.
Okano et al. (1991) J. of Neurochemistry 56(2) 560-567.
Cunningham et al. (1989) Science 244:1081-1085.
Subasinghe et al. (1988) Nucleic Acids Research 16:3209-3221.
Thompson et al. (1994) Nucleic Acids Research 22:4673-4680.
Monreal A. et al. American Journal Human Genetics, vol. 63, No. 2, pp. 380-389 (1998).
Belvin, M et al. Annu. Rev. Cell Dev. Biol. Vol. 12, pp. 393-416 (1996).
Tracey, K, et al.Annu Rev Med. vol. 45, pp. 491-503 (1994).
Maini R. et al. Annu. Rev. Med. vol. 51, pp. 207-229 (2000).
Papadakis, K et al., Annu Rev. Med. vol. 51, pp. 289-298 (2000).
Vassalli, P., Annu Rev Immunology, vol. 10, pp. 411-452 (1992).
Saxne et al. Arthritis and Rheumatism, vol. 31, No. 8, pp. 1041-1045 (1988).
Chu et al, Arthritis and Rheumatism, vol. 34, No. 9, pp. 1125-1132 (1991).
Nagai et al, Biochem Biophys Res Commun, vol. 269. No. 2, pp. 532-536 (2000).
Latini et al, Cardiovasc Pharmacology, vol. 23, pp. 1 to 6 (1994).
Anderson et al, Cell, vol. 42. No. 3, pp. 791-798 (1985).
Banner et al, Cell, vol. 73, No. 3, pp. 431-445 (1993).
Goodwin et al, Cell, vol. 73, No. 3, pp. 447-456 (1993).
Smith et al, Cell , vol. 73, No. 7, pp. 1349-1360 (1993).
Smith et al, Cell, vol. 76, No. 6, pp. 959-962 (1994).
Lemaitre et al, Cell, vol. 86, No. 6, pp. 973-983 (1996).
Lacey et al, Cell, vol. 93, No. 2, pp. 165-176 (1998).
Ollmann et al, Cell, vol. 101, No. 1, pp. 91-101 (2000).
Locksley et al, Cell, vol. 104, pp. 487-501 (2001).
Tautz et al, Chromosoma, vol. 98, No. 2, pp. 81-85 (1989).
Hertz et al, Clinical Genetics, vol. 53, No. 3, pp. 205-209 (1998).
Brand, Development, vol. 118, No. 2, pp. 401-415, (1993).
Hay, Development, vol. 12O, No. 8, pp. 2121-2129 (1994).
Roberts, D, 1998, Dropsophila: A Practical Approach(2nd edition), Oxford University, pp. 85-107 Author of Article, T.A.. Grigliatti.
Mathews et al, Drug Discovery Today, vol. 6, No. 3, pp. 141-149 (2001).
Hollenbaugh et al, The EMBO, Journal vol. 11, No. 12, pp. 4313-4321 (1992).
Bayes et al, Hum. Mol. Genet, vol. 7, No. 11, pp. 1661-1669 (1998).
Mitsuyama M et al, IGAKU-NO-AYUMI, vol. 159, No. 8, 467-470 (1991) *Japanese Only.
Masayasu et al, IGAKU-NO-AYUMI, vol. 159, No. 8, 471-474 (1991) *Japanese Only.
Wiley et al, Immunity, vol. 3, No. 6, pp. 673-682 (1995).
Papadakis et al, Inflamm Bowel Dis. vol. 6, No. 4, pp. 303-313 (2000).
Pitti et al, J. Biol. Chem, vol. 271, No. 22, pp. 12687-12690 (1996).
Wong et al, J. Biol. Chem, vol. 272, No. 40, pp. 25190-25194 (1997).
Peetre et al, J. Clin. Invest, vol. 78, pp. 1694-1700 (1986).
Pagani F., J. Clin. Invest, vol. 90, pp. 389-398 (1992).
Kurt-Jones et al, J. Immunology, vol. 139, pp. 317-2324 (1987).
Macnaul et al, J. Immunology, vol. 145, pp. 4145-4166 (1990).
Brennan, et al, J. Immunology, vol. 22, pp. 1907-1912 (1992).
Brennan et al. J. Rheum, vol. 31, pp. 293-298 (1992).
Bowman et al, J. Immunology, vol. 152, No. 4, pp. 1756-1761 (1994).
Martinez, 1999, J. Invest Dermatol, vol. 113, No. 2, 285-286 (1999).
Ferguson et al, J. Med Genet, vol. 35, No. 2, pp. 112-115 (1998).
Muto et al, Lancet pp. 72-74 (1998).
Margolis et al, Nat. Biotechnolo, vol. 16, No. 4, p. 311 (1998).
Kere et al, Nat. Genet., vol. 13, No. 4, pp. 409-416 (1996).
Beutler et al, Nature, vol. 316, pp. 552-554 (1985).
Millar et al, Nature, vol. 324, No. 73 (1986).
Anderson et al, Nature, vol. 390 pp. 175-179 (1997).
Aderem et al, Nature, vol. 406 pp. 782-787 (2000).
Srivastava et al, Proc Natl Acad Sci USA, vol. 94, No. 24, pp. 13069-13074 (1997).
Rubin et al, Science, vol. 218 pp. 348-353 (1982).
Bevilacqua et al, Science, vol. 243, pp. 1160-1165 (1989).
Lefer et al, Science, vol. 249, pp. 61-64 (1990).
Finkel et al, Science, vol. 257, pp. 387-389 (1992).
Hotamisligil et al, Science, vol. 259 pp. 87-91 (1993).
Khush et al, Trends Genet, vol. 16, pp. 442-449 (2000).
NCBI Entrez, Genbank Accession No. BG636194, Harvey et al. 1997.
NCBI Entrez, Genbank Accession No. BG640917, Harvey et al. 1997.
NCBI Entrez, Genbank Accession No. AI260099, Harvey et al 1997.
NCBI Entrez, Genbank Accession No. AC007414, Celniker et al, Mar. 2001.
NCBI Entrez, Genbank Accession No. AE003831, Adams et al, Oct. 2000.
NCBI Entrez, Genbank Accession No. AC012854,Adams et al, Nov. 1999.
NCBI Entrez, Genbank Accession No. AC005974, Celniker, Nov. 1998.
NCBI Entrez, Genbank Accession No. 014788, Anderson et al. Oct. 2000.
NCBI Entrez, Genbank Accession No. P32970, Goodwin, Oct. 2000.
NCBI Entrez, Genbank Accession No. P32971, Smith et al., Oct. 2000.
NCBI Entrez, Genbank Accession No.P50591, Wiley et al, Oct. 2000.
NCBI Entrez, Genbank Accession No.NP034229, Srivastava et al, Nov. 2000.
NCBI Entrez, Genbank Accession No. Q92838, Kere et al, Oct. 2000.
Kobielak et al., European Journal of Human Genetics, Supp 7 p. 104 (1999).
Hollenbaugh et al., Molecular Biology, Supp 4 CPI, Chptr 10.19-10.10.19.10 (1992).
Bowen Michael A.
Carroll Pamela M.
Chen Jian
Guan Bo
Ramanathan Chandra S.
Bristol--Myers Squibb Company
D'Amico Stephen C.
Klein Christopher A.
Saoud Christine J.
Seharaseyon Jegatheesan
LandOfFree
Dropsophila tumor necrosis factor class molecule... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dropsophila tumor necrosis factor class molecule..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dropsophila tumor necrosis factor class molecule... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3845353