Chemistry: molecular biology and microbiology – Apparatus – Including condition or time responsive control means
Reexamination Certificate
2006-12-15
2010-10-19
Beisner, William H (Department: 1797)
Chemistry: molecular biology and microbiology
Apparatus
Including condition or time responsive control means
C435S287200, C435S288500, C435S293100, C204S547000, C204S643000
Reexamination Certificate
active
07816121
ABSTRACT:
A droplet actuation system is provided including a droplet actuation device including a substrate that includes electrodes for conducting droplet operations; temperature control means for heating and/or cooling a region of the droplet actuation device and arranged such that a droplet can be transported on the electrodes to a region for heating; and a means for effecting a magnetic field in proximity to one or more of the electrodes sufficient to immobilize magnetically responsive beads in a droplet on the substrate during droplet operations. The system further includes a processor for controlling the electrodes and temperature control means, wherein the processor is programmed, and electrodes and magnetic field are arranged, to cause the electrodes to split a droplet including the magnetically responsive beads yielding a first daughter droplet which includes the magnetically responsive beads and a second daughter droplet without a substantial amount of the magnetically responsive beads.
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Paik Philip Y.
Pamula Vamsee K.
Pollack Michael G.
Advanced Liquid Logic, Inc.
Barrett William A.
Beisner William H
Duke University
Ward and Smith P.A.
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