Dried hydrogel from hydrophilic-hygroscopic polymer

Details Dried hydrogel from hydrophilic-hygroscopic polymer Dried hydrogel from hydrophilic-hygroscopic polymer

1993-06-24

1995-04-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424443, 424 7806, 424 7808, 4241451, 424 936, 536128, A61K 970, A61L 1526, A61L 1560

Patent

active

054097037

ABSTRACT:
A therapeutic medical device is described that is comprised of a dried hydrogel of a hydrophilic-hygroscopic polymer, such as an unmodified or modified polymeric carbohydrate, in the form of a solid foam. The dried hydrogel is prepared by preferably freeze-drying a hydrogel of this polymer in a liquid medium, such as water. The dried hydrogel can be sterilized by radiation or other means so that the sterilized product has a relatively indefinite shelf-life without refrigeration. The resultant dried hydrogel can be transformed into a hydrogel upon absorption of addition liquid medium. The described therapeutic device can serve as a dressing for a wound or lesion, drug delivery system, a hemostatic agent and a biologic response modifier. The described therapeutic device enhances the wound healing rate.

REFERENCES:
patent: 4002173 (1977-01-01), Manning et al.
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patent: 4851224 (1989-07-01), McAnalley
patent: 5079018 (1992-01-01), Eranero et al.
patent: 5118673 (1992-06-01), Carpenter et al.
Physician's Desk Reference (1993) on Gelfoam.RTM..
Gelfoam.RTM. (Upjohn): Suppl 4.
Gelfoam.RTM. Products (Upjohn): SS&E Data, approved Jul. 8, 1983.
Gelfoam.RTM. Gelatin Sponge (Upjohn): MOR, PH, TX, CH, Micro, P/I.
Thrombin vs Gelfoam.RTM.--Compatibility DTA & Trans Jan. 6-Jul. 1979 Mtg.

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