Surgery – Means for introducing or removing material from body for... – Treating material applied to or removed from external...
Patent
1989-05-31
1992-09-15
Green, Randall L.
Surgery
Means for introducing or removing material from body for...
Treating material applied to or removed from external...
604304, 424447, 523111, 602 56, A61F 1302
Patent
active
051473399
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to a dressing material for the treatment of wounds in the surface, oral cavity or other accessible mucous membranes of the human body by successive release of at least one substance which is biologically active in wound care and which is discontinuously present in a solid, hydrophobic, water-insoluble, biologically inert, continuous matrix which is stable at temperatures below 50.degree. C. and which forms part of one or more small bodies or corpuscles connected to a bandage intended to be attached to the skin around the wound, preferably by adhesion.
BACKGROUND OF THE INVENTION AND PRIOR ART
A range of bandages are known which are adhesive on the side facing the skin or the wound, especially adhesive plasters, and -- most important in the present context -- in the form of skin barriers having a continuous phase of a skin-friendly, adhesive material preferably comprising an elastomer such as a styrene-olefine-styrene block copolymer, a natural rubber or silicone rubber. The adhesive material may be polymers and copolymers of dicyclopentadiene or pinene, or it may be polyisobutylene or similar substances. According to known technique one or more hydrocolloids may be present as a separate disperse phase. Examples of patent specifications describing this technique are U.S. Pat. No. 3,339,546, U.S. Pat. No. 4,231,369 and U.S. Pat. No. 4,367,732. At least the skin barriers known from the two latter specifications are liquid-absorbing.
In the skin and wound treatment it is known to incorporate biologically active substances, for instance antibiotics and antiseptics, in the continuous phase of such adhesive bandages, cf. e.g. EP patent specification No. 55,023 which recommends the incorporation of antiseptics in order to protect the bandage itself; U.S. Pat. No. 4,307,717; DK patent specification No. 109,225, cf. especially Examples 7-9; U.S. Pat. Nos. 4,231,369 and 4,367,732 referred to above; and the U.S. Pat. Nos. 370,893 of Apr. 22, 1982 and 507,657 of Jun. 27, 1983. European patent publication No. 272,149 suggests incorporating a biologically active substance in a separate phase which is dispersed in the continuous phase, thereby obtaining a liquid-dependent release of the active substance, whereas the active substance is released substantially independently of liquid from the bandages in which it is present in the continuous phase.
From various patent specifications, i.a. EP publication No. 63,604, PCT publication No. W082/00099 and U.S. Pat. No. 3,769,071 it is known to cut sheets of bandages, having incorporated therein a biologically active material, into corpuscles which are placed on the patient on the site of treatment.
From U.S. Pat. No. 4,597,960 an astrigent hemostatic preparation is known which is provided with a granulated hemostatic (an inorganic aluminium or ferric salt) encapsulated in a cellulose-based, biocompatible polymer which is soluble in body fluids. The granulated hemostatic itself may be particles which are attached to an adhesive layer on an absorbing pad, for instance made from gauze or a foam material, and these elements together may form corpuscles which are attached to the adhesive surface of a conventional bandage provided with an adhesive layer. The side of the granulated hemostatic facing the skin may optionally be covered with a further layer of an adhesive which on the side facing the skin is provided with a further absorbing pad of the same kind as that mentioned above. The hemostatic effect will occur when the capsule-forming polymer is dissolved by the body fluids whereby no substantial delay nor protracted effect of the aluminium or ferric salts will occur.
EP patent specification No. 170,010 describes a self-adhesive plaster comprising approximately spherical cap-shaped segments containing one or more biologically active substances arranged on a carrier for transdermal administration and, in order to exert an adhesive effect on the biologically active substance, also comprising approximately spherical cap-shaped
REFERENCES:
patent: 3742951 (1973-07-01), Zaffaroni
patent: 4538603 (1985-09-01), Pawelchak et al.
patent: 4624665 (1986-11-01), Nuwayser
patent: 4699792 (1987-10-01), Nick et al.
patent: 4704119 (1987-11-01), Shaw et al.
Coloplast A/S
Green Randall L.
Prebilic Paul
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