Dressing for dosing one or more medicaments

Details Dressing for dosing one or more medicaments Dressing for dosing one or more medicaments

1995-02-27

2000-11-28

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61L 1544

Patent

active

061532150

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

The present invention concerns a dressing containing one or more active medicaments for controlled release.
Various bandages or dressings of this type are known, consisting of of the bandage which is not intended to face the patient's skin. containing an adhesive and e.g. composed of an elastomer, a plasticizer for elastomers, a tackifying resin and optionally an oil-based extender as well as an antioxidant, and optionally one or more water soluble or water swellable hydrocolloids, such as starch or cellulose derivatives or other hydrophilic polymers, as well as medicaments, such as antiseptics, antibiotics and antiinflammatory agents.
Such bandages, which are primarily intended for use on wounded skin areas, are known e.g. from EP Patent Applications Nos. 92999 and 122344 as well as from DK Patent No. 154 806.
Other bandages of a similar type, but which are also used for transcutaneous medication, are known from U.S. Pat. No. 4,904,247 and from EP Patent Application No. 186019.
With the exception of the bandage known from DK Patent No. 154 806, it is not possible to control or regulate the release of medicament from the bandages mentioned above.
Thus, in the use of these known bandages the initial release will be very great, following which the release of the medicaments decreases evenly.
The adhesive layer of the bandage described in DK Patent No. 154 806 consists of a continuous water insoluble phase and a discontinuous phase which is dispersed in it and which is water soluble or water swellable, said discontinuous phase incorporating the medicament. Thus, the incorporated medicament will be released in step with the solution or swelling of liquid in the discontinuous phase, and there is thus no control of the release of the medicament.
However, a great initial release and a following declining release of the medicament can still be observed when the bandage is used on exuding wounds, and in particular if the wounds are very exuding.
Such a release profile is desired in some situations, but in other situations another release profile is desired, such as release of a constant amount of the medicament per unit of time or delayed release.
Furthermore, U.S. Pat. No. 4,904,247 describes a liquid absorbing wound bandage comprising an adhesive absorbing layer intended to face the user as well as a non-adhesive layer, wherein one of the layers or both may contain a medicament for transdermal release.
The two layers are hydrogels consisting of mixtures of hydrophilic and hydrophobic polymers, the mixture in the adhesive layer comprising at least 80% hydrophilic polymer forming a continuous matrix in which the hydrophobic polymer is dispersed.
The release of medicaments takes place by dispersion through the hydrophilic moist matrix. Thus, theoretically it is possible to obtain delayed release of the medicament by selecting an adhesive hydrogel layer without medicament. However, in practice the medicament spreads in the layers during storage, thus resulting in a release profile of the medicament which corresponds to the one obtained with the bandages mentioned above.
U.S. Pat. No. 4,781,924 discloses a bandage for release of one or more medicaments at a predetermined rate, said bandage consisting of several layers, wherein the active compound is incorporated in a first form in which it cannot be released and is changed to another form by an activating compound, which is additionally activated by water. Thus, the release from this bandage is likewise regulated by liquid action, and the release profile is substantially analogous with the release profile of the bandage known from DK Patent No. 154 806, it being possible, however, to obtain delayed release of the medicament. Thus, this bandage can only be used for quite few medicament systems and is moreover rather expensive to manufacture.
NO Published Application No. 163 438 discloses a plaster comprising a medicament reservoir which is coated with a semipermeable or perforated film membrane on the central part of the side facing the ski

REFERENCES:
patent: 4904247 (1990-02-01), Therriault et al.
patent: 5066494 (1991-11-01), Becher
patent: 5132115 (1992-07-01), Wolter
patent: 5149538 (1992-09-01), Granger
patent: 5176915 (1993-01-01), Hoffmann
patent: 5230898 (1993-07-01), Horstmann

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