DPP-IV inhibitor including beta-amino group, preparation...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S384000

Reexamination Certificate

active

08030315

ABSTRACT:
The present invention provides a novel heterocyclic compound containing a beta-amino group, a method for preparing the same, and a pharmaceutical composition comprising the same heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient. The heterocyclic compound of the present invention exhibits excellent DPP-IV inhibitory activity and bioavailability and therefore can be useful for the prophylaxis or treatment of DPP-IV-related diseases such as diabetes or obesity.

REFERENCES:
patent: 2004/037169 (2004-05-01), None
patent: 2005/011581 (2005-02-01), None
patent: 2005/056003 (2005-06-01), None
patent: 2005/056541 (2005-06-01), None
patent: 2005/095343 (2005-10-01), None
patent: 2005/121131 (2005-12-01), None
patent: 2005/123685 (2005-12-01), None
patent: WO 2005/123685 (2005-12-01), None
patent: 2006/104997 (2006-10-01), None
Biftu, et al., (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2- trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes, Bioorganic & Medicinal Chemistry Letters, 2007, 17:49-52.
Coumar, et al., 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes, Bioorganic & Medicinal Chemistry Letters, 2007, 17:1274-1279.

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