Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1976-12-07
1978-04-25
Rosen, Sam
Drug, bio-affecting and body treating compositions
Lymphokine
424227, A61K 3179, A61K 3165
Patent
active
040863328
ABSTRACT:
Aqueous solutions of doxycycline or salts thereof, a pharmaceutically acceptable soluble magnesium compound and 2-pyrrolidone as a co-solvent, said solution having a pH of 3 to 7.5 and being useful as an injectable composition combining low viscosity, high potency, good clarity and good stability.
REFERENCES:
patent: 2987437 (1961-06-01), Hessel
patent: 3062717 (1962-11-01), Hammer
patent: 3674859 (1972-07-01), Beutel et al.
patent: 3932653 (1976-01-01), Stoughton
patent: 3957980 (1976-05-01), Noseworthy
patent: 3957994 (1976-05-01), Schroer
patent: 3969516 (1976-07-01), Stoughton
Japanese Pat. Appln. Pub. No. Sho 47-303 (Jan. 6, 1972).
Japanese Pat. Appln. Pub. No. Sho 43-1758 (Jan. 22, 1968).
Gans & Higuchi-J. Pharm. Sci. vol. 46 (1957) p. 458.
Knuth Charles J.
Murphy Francis X.
Pfizer Inc.
Rosen Sam
Spiegel Allen J.
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